Mouse Anti-CREB3L4 Recombinant Antibody (VS3-FY2673) (CAT#: VS3-FY2673)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• CAMP responsive element binding protein 3 like 4 of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 43.4 kDa.

• Related Disease
• Hepatic Adenomas, Familial and Congenital Myopathy 4A, Autosomal Dominant

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• CAMP Responsive Element Binding Protein 3 Like 4; CAMP-Responsive Element-Binding Protein 3-Like Protein 4; Cyclic AMP-Responsive Element-Binding Protein 4; Transcript Induced In Spermiogenesis Protein 40; Androgen-Induced Basic Leucine Zipper Protein; CAMP-Responsive Element-Binding Protein 4; Attaching To CRE-Like 1; Tisp40; AIBZIP

• Gene ID
• 148327

• UniProt ID
• Q8TEY5

• Sequence Similarities
• Belongs to the bZIP family. ATF subfamily.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• N-glycosylated in the C-terminal region.
  Controlled by regulated intramembrane proteolysis (RIP).
  Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis.
  The cleavage seems to be performed sequentially by site-1 and site-2 proteases.
  PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
  Glycosylation at Thr339, Thr344, Thr349, Ser354, and Asn366
  Ubiquitination at Lys51 and Lys194
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 7 sites, 1 O-linked glycan (6 sites)

• Protein Refseq
• XP_006711235.1; XP_016855861.1; XP_024309111.1; XP_024309112.1; XP_024309114.1

• Function
• Binds to the UPR element (UPRE) but not to CRE element.
  Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE.
  Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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