Rabbit Anti-FIG4 Recombinant Antibody (clone R02-4C6) (CAT#: VS3-FY1951)

• Immunogen
• Synthetic peptide of human FIG4

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human FIG4

• Species Reactivity
• Human

• Clone
• R02-4C6

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 104 kDa, while the observed molecular weight stands at 104 kDa.

• Related Disease
• Charcot-Marie-Tooth disease, type 4J

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• FIG4 Phosphoinositide 5-Phosphatase; KIAA0274; Phosphatidylinositol 3,5-Bisphosphate 5-Phosphatase; SAC Domain-Containing Protein 3; SAC3; FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (S. Cerevisiae); FIG4 Homolog, SAC1 Domain Containing Lipid Phosphatase; FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing; FIG4 Homolog, SAC Domain Containing Lipid Phosphatase; Sac Domain-Containing Inositol Phosphatase 3; Polyphosphoinositide Phosphatase

• Gene ID
• 9896

• UniProt ID
• Q92562

• Cellular Localization
• Endosome, Membrane

• Post Translation Modifications
• Ubiquitination at Lys379 (NX_Q92562 [NX_Q92562-1])
  Modification sites at PhosphoSitePlus (Q92562)
  Glycosylation from GlyGen (Q92562) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_011534583.1; XP_054212880.1; NP_055660.1

• Function
• Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production.
  In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody