Mouse Anti-H-2Dd/P18-I10 Recombinant Antibody (clone KP14/1) (CAT#: FAMAB-0137JF)
Recombinant monoclonal antibody specially binds to the MHC-I molecule H-2Dd complexed with an antigenic peptide P18-I10. This mouse anti-H-2Dd/P18-I10 antibody KP14/1 could be potencially used in the treatment of patients with autoimmunity disease.
Specific Inquiry
FC
Figure 1 Expression of ScDd in the absence of normal β2m.
Analysis for the expression of MHC-I molecules was performed on the gated CD4-positive cells.
Margulies, D. H., Berzofsky, W. M. Y., Mage, M. G., Natarajan, I. M. B., Hunziker, R., & Jay, A. (1999). NK and CTL Recognition of a Single Chain. J Immunol, 163, 3699-3708.
WB
Figure 2 Immunoprecipitation of transgenic Sc H-2Dd.
The lysates were precipitated with 34-2-12 (anti-α3 of H-2Dd ) and protein-G Sepharose beads, washed, separated on 14% SDS polyacrylamide gel, and transferred to Immobilon P membrane.
Margulies, D. H., Berzofsky, W. M. Y., Mage, M. G., Natarajan, I. M. B., Hunziker, R., & Jay, A. (1999). NK and CTL Recognition of a Single Chain. J Immunol, 163, 3699-3708.
FuncS
Figure 3 H-2Db tetramer staining of the mutated Ly-49C receptors mirrored H-2Kb staining.
The data shown are average of three to nine independent experiments ± SE.
Lindström, H., Kärre, K., Sundbäck, J., Achour, A., & Michaëlsson, J. (2002). NK Cell Inhibitory Receptor Ly-49C Residues. J Immunol, 168, 793-800.
Specifications
- Immunogen
- H-2Dd/P18-I10 peptide complex
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- 2Dd/P18-I10 peptide complex
- Clone
- KP14/1
- Applications
- WB, FC, FuncS
- Related Disease
- Autoimmunity disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The H-2Dd/P18-I10 antibody has been reported in applications of Flow Cytometry, Functional Assay, Western Blot.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160; precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
- Function
- Inhibition of T cell recognition
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0137JF-F(E) | Mouse Anti-H-2Dd/P18-I10 Recombinant Antibody (clone KP14/1); Fab Fragment | FC, IF, ELISA, FuncS | Mouse Fab |
| FAMAB-0138JF-F(E) | Mouse Anti-H-2Dd/P18-I10 Recombinant Antibody (clone KP15/11); Fab Fragment | FC, IF, ELISA, FuncS | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0137JF-S(P) | Mouse Anti-H-2Dd/P18-I10 Recombinant Antibody (clone KP14/1); scFv Fragment | FC, IF, ELISA, FuncS | Mouse scFv |
| FAMAB-0138JF-S(P) | Mouse Anti-H-2Dd/P18-I10 Recombinant Antibody (clone KP15/11); scFv Fragment | FC, IF, ELISA, FuncS | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0138JF | Mouse Anti-H-2Dd/P18-I10 Recombinant Antibody (clone KP15/11) | FC, IF, ELISA, FuncS | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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