Recombinant Anti-HIV gp120 Biparatopic Antibody, Tandem scFv (Clone 257-D x Clone m14)
CAT#: VS-0525-YC97
The Recombinant Anti-HIV gp120 Biparatopic Antibody, Tandem scFv (Clone 257-D x Clone m14) is a biparatopic antibody (bpAb) engineered to recognize two distinct HIV gp120 epitopes. The bpAb's tandem scFv format includes the 257-D scFv (binding amino acids KRIHI) N-terminally joined to the m14 scFv (specific for a critical CD4 binding site: SSGGDPEIVTH).
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- HIV gp120
- Species Reactivity
- HIV
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- 257-D
- Clone 2
- m14
- Epitope 1
- Amino acids sequence: KRIHI
- Epitope 2
- Amino acids sequence: SSGGDPEIVTH, a CD4 binding site.
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- HIV virus glycoprotein gp120
Target
- Introduction
- The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells, apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. gp120 was discovered by Professors Tun-Hou Lee and Myron "Max" Essex of the Harvard School of Public Health in 1988. The 120 in its name comes from its molecular weight of 120 kDa. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds. Env is a viral gene that encodes the protein forming the viral envelope. The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane. Env is a viral gene that encodes the protein forming the viral envelope. The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane.
- Alternative Names
- Human immunodeficiency virus; HIV; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
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Datasheet
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COA
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|---|---|---|---|
| DrMAB-136 | Human Anti-HIV gp120 Recombinant Antibody (clone HGD65) | Neut | Human IgG1, λ |
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| HPAB-0555YY | Human Anti-HIV gp120 Recombinant Antibody (clone DRVIA7H+gDRVI01-L40) | ELISA, Neut | Human IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-412-F(E) | Recombinant Anti-HIV gp120 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-412-F(E) | Recombinant Human Anti-HIV gp120 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
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| FAMAB-0177WJ-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone SF12); Fab Fragment | ELISA, WB, Neut | Human Fab |
| PABJ-0031-F(E) | Bovine Anti-HIV gp120 Recombinant Antibody; Fab Fragment (PABJ-0031-F(E)) | ELISA, Neut | Bovine Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B053(A) | Recombinant Anti-HIV gp120 Intrabody [(D-Arg)9] | ELISA, ICC, FuncS | scFv-(D-Arg)9 |
| IAB-B053(G) | Recombinant Anti-HIV gp120 Intrabody [+36 GFP] | PCA, Neut, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-412-S(P) | Recombinant Human Anti-HIV gp120 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| PSBL-507 | Human Anti-HIV gp120 Recombinant Antibody (clone PGT127); scFv Fragment | ELISA, Neut | Human scFv |
| HPAB-1452-FY-F(E) | Human Anti-HIV gp120 Recombinant Antibody; Fab Fragment (HPAB-1452-FY-F(E)) | Neut | Human Fab |
| HPAB-1454-FY-F(E) | Human Anti-HIV gp120 Recombinant Antibody; Fab Fragment (HPAB-1454-FY-F(E)) | Neut | Human Fab |
| HPAB-0556YY-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone DRVIA7H+gDRVI01-L57); scFv Fragment | ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-023LC | Anti-HIV gp120 Recombinant Antibody (HY498) | ELISA | Human antibody |
| MRO-182LC | Anti-HIV gp120 Recombinant Antibody (58.2) | ELISA | Human antibody |
| MRO-183LC | Anti-HIV gp120 Recombinant Antibody (59.1) | ELISA | Human antibody |
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| MRO-183LC-S(P) | Anti-HIV gp120 Recombinant Antibody scFv Fragment (59.1) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0547YY | Human Anti-HIV gp120 Recombinant Antibody (HPAB-0547YY) | ELISA, FuncS | Human IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY70 | Human Anti-HIV gp120 (clone 2G12) scFv-Fc Chimera | Neut | Human IgG1, scFv-Fc |
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