Human Anti-αIIbβ3 Recombinant Antibody (clone EBB3) (CAT#: FAMAB-0055JF)
Recombinant human monoclonal antibody specially binds to human αIIbβ3. This anti-αIIbβ3 antibody EBB3 can be potentially wildly used in the treatment of Glanzmann thrombasthenia (GT).
Specific Inquiry
WB
Figure 1 JON/A binds to a functionally critical epitope on αIIβ3.
Immunoprecipitation from normal and αIIb3-depleted NP-40 lysates of surface-biotinylated resting platelets with MWReg30 and JON/A.
Bergmeier, W., Schulte, V., Brockhoff, G., Bier, U., Zirngibl, H., & Nieswandt, B. (2002). Flow cytometric detection of activated mouse integrin αIIbβ3 with a novel monoclonal antibody. Cytometry: The Journal of the International Society for Analytical Cytology, 48(2), 80-86.
FC
Figure 2 Flow cytometric analysis of binding of FITC-labeled or PE-labeled JON/A.
The dotted line represents the mean log fluorescence obtained with the respective PE/ FITC-coupled control IgG.
Bergmeier, W., Schulte, V., Brockhoff, G., Bier, U., Zirngibl, H., & Nieswandt, B. (2002). Flow cytometric detection of activated mouse integrin αIIbβ3 with a novel monoclonal antibody. Cytometry: The Journal of the International Society for Analytical Cytology, 48(2), 80-86.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- Human αIIbβ3
- Species Reactivity
- Human
- Clone
- EBB3
- Applications
- WB, FC
- Related Disease
- Glanzmann thrombasthenia
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The αIIbβ3 antibody has been reported in applications of Western Blot, Flow Cytometry.
Target
- Alternative Names
- Integrin αIIbβ3; Integrin Alpha IIb Beta 3; GPIIb/IIIa; glycoprotein IIb/IIIa; ITGA2B; ITGB3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-749 | Mouse Anti-αIIbβ3 Recombinant Antibody (clone 314.3) | WB, IHC, IF, FuncS | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-742 | Mouse Anti-αIIbβ3 Recombinant Antibody (clone 314.3); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| FAMAB-0055JF-F(E) | Human Anti-αIIbβ3 Recombinant Antibody (clone EBB3); Fab Fragment | IB, ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-742 | Mouse Anti-αIIbβ3 Recombinant Antibody (clone 314.3); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| FAMAB-0055JF-S(P) | Human Anti-αIIbβ3 Recombinant Antibody (clone EBB3); scFv Fragment | IB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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