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    Mouse Anti-KMT2A Monoclonal Antibody (clone 10F8D7) (CAT#: VS7-0425-WR393)

    This product is a mouse IgG1 antibody that binds to human KMT2A. The antibody 10F8D7 recognizes specific amino acid domain of MLL (aa3751-3968). It can be used for IHC assay.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/44910/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebellum.
    Figure 2 Cerebellum.
    (High expression in cerebellum)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17794/42699_B_9_8_val_selected.jpg
    Figure 3 Testis
    Figure 3 Testis
    (Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/24270/146580_A_6_6.jpg
    Figure 4 Lymph node
    Figure 4 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/24270/146580_A_8_8.jpg
    Figure 5 Cerebral cortex
    Figure 5 Cerebral cortex
    (Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/24270/146580_B_8_5.jpg
    Figure 6 Colon
    Figure 6 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/24270/146580_A_8_3.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/24270/146580_A_8_5.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118058-KMT2A

    Specifications

    • Immunogen
    • Recombinant MLL (aa3751-3968) fragment expressed in E. Coli.
    • Host Species
    • Mouse
    • Type
    • Mouse IgG1
    • Specificity
    • Human KMT2A
    • Species Reactivity
    • Human
    • Clone
    • 10F8D7
    • Molecule Class
    • Mixed Lineage Leukemia
    • Applications
    • IHC
    • Conjugate
    • Unconjugated
    • Related Disease
    • Wiedemann-Steiner syndrome (WDSTS)

    Product Property

    • Clonality
    • Monoclonal
    • Purity
    • >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Preservative
    • 0.03% sodium azide
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Western Blot: 1:500 - 1:2000
      Immunohistochemistry-Paraffin: 1:200 - 1:1000
      Enzyme-linked Immunosorbent Assay: 1:10000

    Target

    • Alternative Names
    • KMT2A; CXXC7; MLL1A; MLL/GMPS Fusion Protein; MLL/GAS7; Trithorax-Like Protein; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; HTRX1; MLL1; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); MLL/GAS7 Fusion Protein; ALL1; Myeloid/Lym
    • Long Name
    • Lysine Methyltransferase 2A
    • Cellular Localization
    • Nucleus
    • Post Translation Modifications
    • Acetylation; Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation
    • Function
    • Chromatin regulator; DNA-binding; Methyltransferase; Transferase

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 10F8D7"

    See other products for "KMT2A"

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    IgG Antibodies
    CAT Product Name Application Type
    MOB-3092z Mouse Anti-KMT2A Recombinant Antibody (clone 11B11) WB, ELISA, IHC Mouse IgG1
    ZG-0285C Mouse Anti-KMT2A Recombinant Antibody (ZG-0285C) WB, IHC, ELISA Mouse IgG
    VS3-XY991 Mouse Anti-KMT2A Recombinant Antibody (clone 10F8D7) ELISA, WB, IHC Mouse IgG1
    VS3-FY800 Recombinant Mouse Anti-KMT2A Antibody (clone 7E1D10) ELISA, IHC, ICC, FC Mouse IgG1
    VS7-0425-WR394 Mouse Anti-KMT2A Monoclonal Antibody (VS7-0425-WR394) WB, IHC-P, IF, ELISA Mouse IgG

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