AbPlus™ Anti-LAMC2 Magnetic Beads (VS-0724-YC969)
CAT#: VS-0724-YC969
The AbPlus Anti-LAMC2 Magnetic Beads (VS-0724-YC969) is an innovative affinity resin which is bound with anti-LAMC2 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of LAMC2 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to endoplasmic reticulum & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24638/972_E1_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46539/835_H11_2_selected.jpg
Normal Tissue
Figure 3 IHC staining of human vagina
Immunohistochemical staining of human vagina shows strong positivity in basal membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4257/163632_B_1_2_selected.jpg
Normal Tissue
Figure 4 IHC staining of human fallopian tube
High expression. RNA expression: 34.9 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78165/162944_A_7_7_val_selected.jpg
Normal Tissue
Figure 5 IHC staining of human prostate
Low expression. RNA expression: 5.4 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78165/162944_A_2_5_val_selected.jpg
Normal Tissue
Figure 6 Cerebral cortex
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4257/163632_B_8_5.jpg
Normal Tissue
Figure 7 Oral mucosa
Squamous epithelial cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4257/163632_A_9_1.jpg
Normal Tissue
Figure 8 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78165/162944_A_7_3.jpg
Normal Tissue
Figure 9 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4257/163632_A_8_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in tubules
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4257/163632_A_9_5.jpg
Normal Tissue
Figure 11 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4257/163632_A_5_6.jpg
RNA Expression
Figure 12 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HBEC3-KT, hTERT-HME1, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000058085-LAMC2
❮
❯
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-LAMC2 specific antibody
- Target
- LAMC2
- Immunogen
- Recombinant human LAMC2 fragment derived from E. coli.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction.
- Alternative Names
- B2T; CSF; EBR2; BM600; EBR2A; JEB3A; JEB3B; LAMB2T; LAMNB2
- Gene ID
- 3918
- UniProt ID
- Q13753
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| MOB-1691z | Mouse Anti-LAMC2 Recombinant Antibody (clone 32D4) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| MOB-0315MZ | Recombinant Mouse Anti-Human LAMC2 Antibody (clone 5H2) | IHC | Mouse antibody |
| CAT | Product Name | Application | Type |
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| VS-0525-XY3936 | Anti-LAMC2 Immunohistochemistry Kit | IHC |
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