PTM™ Rabbit Anti-LRRK2 (pSer935) Recombinant Antibody (VS13-YC673) (CAT#: VS13-YC673)
The PTM™ Rabbit Anti-LRRK2 (pSer935) Recombinant Antibody is a post-translational modification (PTM) antibody specific for the phosphorylated LRRK2 (Ser935) of human and mouse. The phosphorylation of the LRRK2 protein at serine 935 may influence LRRK2 activity and is linked to its role in Parkinson's disease (PD). The anti-LRRK2 (pSer935) antibody can be used for Western blot (1/500-1/1000), Immunofluorescence (1/50-1/200).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- Recombinant human phosphorylated LRRK2 (pSer935).
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- The phosphorylated LRRK2 (Ser935) of human and mouse.
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF
- Conjugate
- NONE
- Related Disease
- Parkinson disease
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 150 mM NaCl and 50% Glycerol.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunofluorescence (IF): 1/50-1/200
Target
- Alternative Names
- PARK8; RIPK7; ROCO2; AURA17; DARDARIN
- Gene ID
- 120892
- UniProt ID
- Q5S007
- Long Name
- leucine rich repeat kinase 2
- Cellular Localization
- Cytoplasmic vesicle; Perikaryon; Golgi apparatus membrane; Cell projection; axon
- Protein Refseq
- XP_011536179.1; XP_005268686.1
- Function
- Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking.
Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation.
Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43.
Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A.
Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
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