Human Anti-NoV GII.4 Recombinant Antibody (clone NVB43.9) (CAT#: FAMAB-1786CQ)
This product is a recombinant human antibody that recognizes NoV GII.4. The antibody was purified by affinity chromatography. It can be used in Neut.
Specific Inquiry
FuncS
Figure 1 Blockade of Bi-HBGAs by Hu mAb.
Bi-HBGA binding blockade activity of NBV 43.9.
Lindesmith, L. C., Beltramello, M., Donaldson, E. F., Corti, D., Swanstrom, J., Debbink, K., ... & Baric, R. S. (2012). Immunogenetic mechanisms driving norovirus GII. 4 antigenic variation. PLoS pathogens, 8(5), e1002705.
Figure 2 Epitope A comprises an evolving GII.4 blockade epitope recognized by 43.9.
Hu mAb PGM binding blockade activity against GII.4.1987 epitope-exchanged VLPs for NVB 114 and Epitope A exchanged between GII.4.1987 and GII.4.2006.
Lindesmith, L. C., Beltramello, M., Donaldson, E. F., Corti, D., Swanstrom, J., Debbink, K., ... & Baric, R. S. (2012). Immunogenetic mechanisms driving norovirus GII. 4 antigenic variation. PLoS pathogens, 8(5), e1002705.
FuncS
Figure 3 Human mAbs NVB 111 and 43.9 recognize a blockade epitope restricted to Minerva variants.
Panel A (NVB 111) and C (NVB 43.9): PGM binding blockade activity. Sigmoidal curves were fit to the mean percent control binding calculated by comparing the amount of VLP bound to PGM in the presence of antibody pretreatment to the amount of VLP bound in the absence of antibody pretreatment. Error bars represent the standard error of the mean. Panels B (NVB 111) and D (NVB 43.9): Mean EC50 (µg/ml) for blockade of each VLP. * VLP with EC50 value significantly different from the EC50 for GII.4.2006.
Lindesmith, L. C., Beltramello, M., Donaldson, E. F., Corti, D., Swanstrom, J., Debbink, K., ... & Baric, R. S. (2012). Immunogenetic mechanisms driving norovirus GII. 4 antigenic variation. PLoS pathogens, 8(5), e1002705.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- NoV GII.4
- Species Reactivity
- Norovirus
- Clone
- NVB43.9
- Applications
- Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- NoV GII.4; NoV; Norovirus; Caliciviridae
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2331CQ | Recombinant Mouse Anti-NoV GII.4 Antibody (VC3) | ELISA | Mouse antibody |
| MRO-2332CQ | Recombinant Mouse Anti-NoV GII.4 Antibody (VC20) | ELISA | Mouse antibody |
| MRO-2333CQ | Recombinant Mouse Anti-NoV GII.4 Antibody (MRO-2333CQ) | ELISA | Mouse antibody |
| MRO-2334CQ | Recombinant Mouse Anti-NoV GII.4 Antibody (MRO-2334CQ) | ELISA | Mouse antibody |
| MRO-2335CQ | Recombinant Mouse Anti-NoV GII.4 Antibody (MRO-2335CQ) | ELISA | Mouse antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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