Rabbit Anti-PACSIN3 Recombinant Antibody (clone R04-1F1) (CAT#: VS3-FY1957)

• Immunogen
• Synthetic peptide of human PACSIN3

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human PACSIN3

• Species Reactivity
• Human

• Clone
• R04-1F1

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 48 kDa, while the observed molecular weight stands at 48 kDa.

• Related Disease
• Scapuloperoneal Spinal Muscular Atrophy and Metatropic Dysplasia

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• Protein Kinase C And Casein Kinase Substrate In Neurons 3; SH3 Domain-Containing Protein 6511; Syndapin III; Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3; SDPIII

• Gene ID
• 29763

• UniProt ID
• Q9UKS6

• Sequence Similarities
• Belongs to the PACSIN family.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane

• Post Translation Modifications
• Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). (Q9UKS6-PACN3_HUMAN)
  Modification sites at PhosphoSitePlus (Q9UKS6)
  Modification sites at neXtProt (NX_Q9UKS6)
  Glycosylation from GlyGen (Q9UKS6) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_047282806.1; XP_047282807.1; XP_047282808.1; XP_047282809.1; XP_047282810.1

• Function
• Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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