Human Anti-Phospholipid Recombinant Antibody (clone LJ1) (CAT#: FAMAB-0015WJ)
This product is a human antibody developed by fusing the peripheral blood lymphocytes of three patients with SLE with a mouse human heteromyeloma cell line. This antibody binds to a variety of anionic phospholipids, total histones but none binds to ssDNA or dsDNA.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 LJ1 MoAb binds cells undergoing apoptosis.
The binding of LJ1 MoAb to U937 cells was evaluated in a cell population treated with the apoptotic stimulus. 'early' apoptotic cells with low propidium iodide staining (lower right quadrant) and 'late' apoptotic cells with higher propidium iodide staining (upper right quadrant).
Pittoni, V., Ravirajan, C. T., Donohoe, S., Machin, S. J., Lydyard, P. M., & Isenberg, D. A. (2000). Human monoclonal anti‐phospholipid antibodies selectively bind to membrane phospholipid and β2‐glycoprotein I (β2‐GPI) on apoptotic cells. Clinical & Experimental Immunology, 119(3), 533-543.
Specifications
- Host Species
- Human
- Type
- Human IgG3, λ
- Specificity
- Phospholipid
- Clone
- LJ1
- Applications
- FC, ELISA
- Related Disease
- Systemic lupus erythematosus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The Phospholipid antibody has been reported in applications of Flow Cytometry, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Phospholipid
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgM Antibody Products
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1133-CN | Mouse Anti-Phospholipid Recombinant Antibody (HPAB-1133-CN) | WB, ELISA, IF, IHC, FC | Mouse IgM, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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