Mouse Anti-PKD1 Recombinant Antibody (clone 8C3D11) (CAT#: VS7-0425-WR619)

• Immunogen
• Recombinant mouse PKD1 (AA: 3682-3873) fragment expressed in E. Coli.

• Host Species
• Rat

• Type
• Rat IgG1

• Specificity
• Human PKD1

• Species Reactivity
• Human

• Clone
• 8C3D11

• Molecule Class
• Transmembrane Protein

• Applications
• FC

• Conjugate
• Unconjugated

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• 0.05% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Flow Cytometry: 1:200 - 1:400
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• PC1; mFLJ00285

• Gene ID
• 18763

• UniProt ID
• O08852

• Long Name
• Polycystin 1, Transient Receptor Potential Channel Interacting

• Cellular Localization
• Cell membrane; Cell projection; Cilium; Endoplasmic reticulum; Golgi apparatus; Membrane; Secreted

• Post Translation Modifications
• Autocatalytic cleavage; Disulfide bond; Glycoprotein; Phosphoprotein

• Protein Refseq
• NP_038658.2

• Function
• Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity).; Involved in renal tubulogenesis (PubMed:24939912).; Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735).; Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584).; The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (By similarity).

Isotype Control

• MOB-209CQ
• Rat IgG1, kappa Isotype Control Antibody

• MOB-210CQ
• Rat IgG1, lambda Isotype Control Antibody

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