Recombinant Anti-SARS-CoV-2 RBD Biparatopic Antibody, Symmetric IgG-sdAb
CAT#: VS-0525-YC11
This is a neutralizing biparatopic antibody against SARS-CoV-2, binding with high affinity to two non-overlapping epitopes on the Receptor-Binding Domain (RBD). It effectively blocks RBD attachment to human Angiotensin-Converting Enzyme 2 (ACE2) and potently neutralizes SARS-CoV-2, showing IC50 values of 30 pM for Omicron (BA.1) and 50 pM for Delta in pseudovirus assays. The antibody could be effective against all current variants of concern (VOCs) of SARS-CoV-2.
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- SARS-CoV-2 RBD
- Species Reactivity
- SARS-CoV-2
- Type
- Symmetric IgG-sdAb
- Valency
- 2 + 2
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, Neut, SPR
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD)
Target
- Introduction
- The 140 kDa SARS-CoV-2 S protein is organized into two major subunits (S1 and S2) connected by a furin-cleavage site. The S1 subunit contains the receptor-binding domain (RBD; aa 319-541), a 25 kDa domain that is directly involved in the interaction with the Angiotensin-converting enzyme 2 (ACE2). The RBD contains nine cysteines, including eight that form disulfide-bridges involved in the RBD fold. In addition, the domain displays two N-glycosylation sites (Asn331 and Asn343) known to participate in folding, stability and function. Mutations occurring within this domain are constantly monitored to predict the emergence of novel variants that could be naturally selected and quickly spread, such as the recent isolated alpha (B.1.1.7), beta (B.1.351), gamma (P.1) and delta (B.1.617.2) variants of concern.
- Alternative Names
- SARS-CoV S protein; RBD Domain
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0623-WK21 | Human Anti-SARS-CoV-2 RBD Recombinant Antibody (clone JMB2002) | ELISA, BLI, Inhib, Neut | Human IgG |
| VS-0723-WK299 | Rabbit Anti-SARS-CoV-2 RBD Recombinant Antibody (VS-0723-WK299) | ELISA, FC | Rabbit IgG |
| VS-0723-WK310 | Rabbit Anti-SARS-CoV-2 RBD Recombinant Antibody (VS-0723-WK310) | ELISA, FC | Rabbit IgG |
| MOB-366YC | Human Anti-SARS-CoV-2 RBD Recombinant Antibody (MOB-366YC) | ELISA, Neut | Human IgG1 kappa |
| MOB-367YC | Mouse Anti-SARS-CoV-2 RBD Recombinant Antibody (MOB-367YC) | ELISA, Neut | Mouse IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY108 | Human Anti-SARS-CoV-2 RBD (clone II62) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| VS-0325-FY45 | Human Anti-SARS-CoV-2 RBD (clone S15) scFv-Fc Chimera | Neut | Human IgG1, scFv-Fc |
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