Mouse Anti-SNX3 Recombinant Antibody (clone 2506W51) (CAT#: VS-0625-FY86)

• Immunogen
• Antibody specific for an epitope mapping between amino acids 122-162 near the C-terminus of human SNX3.

• Host Species
• Mouse

• Type
• Mouse IgG1, kappa

• Species Reactivity
• Human

• Clone
• 2506W51

• Applications
• Western Blot, Immunoprecipitation, Immunofluorescence, ELISA

• Related Disease
• Microphthalmia, Syndromic 8 and Combined Oxidative Phosphorylation Deficiency 8

• Purification
• Purified with Protein A or G affinity chromatography

• Purity
• >90% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Optimal dilutions for assays should be determined by the user.

• Alternative Names
• Sorting Nexin 3; Sorting Nexin 3A; Sorting Nexin-3; Protein SDP3; MCOPS8; Grd19; SDP3

• Gene ID
• 8724

• UniProt ID
• O60493

• Long Name
• Sorting Nexin 3

• Sequence Similarities
• Belongs to the sorting nexin family.

• Cellular Localization
• Early endosome {ECO:0000269 PubMed:11433298, 21725319, 30213940}
  Cytoplasmic vesicle, phagosome

• Post Translation Modifications
• Ubiquitinated, leading to its proteasomal degradation.
  Deubiquitinated by USP10.
  Ubiquitination at Lys95, Lys119, and Lys128
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site, 1 O-linked glycan

• Protein Refseq
• NP_001287857.1; NP_001287858.1; NP_003786.1; NP_690040.1

• Function
• Phosphoinositide-binding protein required for multivesicular body formation.
  Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)).
  Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity).
  Plays a role in protein transport between cellular compartments.
  Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS).
  May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway.

Secondary Antibody

• 2ND-047CQ
• Goat Anti-Mouse IgG1 Antibody, R-PE

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

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