Rabbit Anti-SRSF6 Recombinant Antibody (clone R39-4Y-8)
CAT#: VS3-FY2166
This is a unmodified rabbit recombinant monoclonal antibody that demonstrated capability to target human SRSF6. The calculated molecular weight of the protein is 40 kDa; the estimated observed molecular weight is about 38-45 kDa. The R39-4Y-8 is recommended for dilution with western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/100-1/200).
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SRSF6
- Species Reactivity
- Human
- Clone
- R39-4Y-8
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- MW
- The calculated weight of the target protein is approximately 40kDa, while the observed molecular weight stands at 38-45kDa.
- Related Disease
- Takayasu Arteritis and Aortitis
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/100-1/200
Target
- Alternative Names
- Serine And Arginine Rich Splicing Factor 6; Splicing Factor, Arginine/Serine-Rich 6; Serine/Arginine-Rich Splicing Factor 6; Pre-MRNA-Splicing Factor SRP55; SR Splicing Factor 6; SFRS6; SRP55
- Gene ID
- 6431
- UniProt ID
- Q13247
- Sequence Similarities
- Belongs to the splicing factor SR family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Extensively phosphorylated on serine residues in the RS domain.
Phosphorylated by DYRK1A, probably in the RS domain.
Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
(Q13247-SRSF6_HUMAN)
Ubiquitination at Lys127, Lys143, and Lys165 (NX_Q13247 [NX_Q13247-1])
Modification sites at PhosphoSitePlus (Q13247)
Glycosylation from GlyGen (Q13247) 4 sites, 1 O-linked glycan (4 sites)
- Protein Refseq
- XP_047296328.1; XP_054179816.1; NP_006266.2
- Function
- Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SRSF6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6911 | Anti-SRSF6 Immunohistochemistry Kit | IHC |
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