Rabbit Anti-SRSF6 Recombinant Antibody (clone R39-4Y-8) (CAT#: VS3-FY2166)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human SRSF6

• Species Reactivity
• Human

• Clone
• R39-4Y-8

• Applications
• Western Blot, Immunohistochemistry-Paraffin

• Conjugate
• Unconjugated

• MW
• The calculated weight of the target protein is approximately 40kDa, while the observed molecular weight stands at 38-45kDa.

• Related Disease
• Takayasu Arteritis and Aortitis

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.4), 150 mM NaCl, 50% glycerol

• Preservative
• 0.02% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/100-1/200

• Alternative Names
• Serine And Arginine Rich Splicing Factor 6; Splicing Factor, Arginine/Serine-Rich 6; Serine/Arginine-Rich Splicing Factor 6; Pre-MRNA-Splicing Factor SRP55; SR Splicing Factor 6; SFRS6; SRP55

• Gene ID
• 6431

• UniProt ID
• Q13247

• Sequence Similarities
• Belongs to the splicing factor SR family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Extensively phosphorylated on serine residues in the RS domain.
  Phosphorylated by DYRK1A, probably in the RS domain.
  Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
  (Q13247-SRSF6_HUMAN)
  Ubiquitination at Lys127, Lys143, and Lys165 (NX_Q13247 [NX_Q13247-1])
  Modification sites at PhosphoSitePlus (Q13247)
  Glycosylation from GlyGen (Q13247) 4 sites, 1 O-linked glycan (4 sites)

• Protein Refseq
• XP_047296328.1; XP_054179816.1; NP_006266.2

• Function
• Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody