Mouse Anti-TAB2 Monoclonal Antibody (VS7-0425-WR946) (CAT#: VS7-0425-WR946)

• Immunogen
• Recombinant human TAB2 fragment expressed in E. Coli.

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human TAB2

• Species Reactivity
• Human

• Molecule Class
• Activator Of Map3K7/Tak1

• Applications
• WB, FC, ELISA

• Conjugate
• Unconjugated

• Related Disease
• Congenital heart defects, multiple types, 2 (CHTD2)

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid

• Format
• Liquid

• Concentration
• 1 mg/ml

• Preservative
• 0.03% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:500 - 1:2000
  Flow Cytometry: 1:200 - 1:400
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 2; Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2; TAK1-Binding Protein 2; MAP3K7IP2; TAB-2; Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2

• Gene ID
• 23118

• UniProt ID
• Q9NYJ8

• Long Name
• TGF-beta activated kinase 1 (MAP3K7) binding protein 2

• Cellular Localization
• Cytoplasm; Endosome; Lysosome; Membrane

• Post Translation Modifications
• Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation

• Protein Refseq
• NP_001278963.1

• Function
• Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF).; Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chain.; The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains.; Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity).; Involved in heart development.;

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

• 2ND-042CQ
• Rabbit Anti-Mouse IgG (H&L) Antibody

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