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    Human Anti-TGM3 Recombinant Antibody (clone DH63-B02) (CAT#: VS-0724-YC56)

    Provided is anti-TG3 antibody DH63-B02, derived from DH patient gut biopsies14. This mAb was chosen as it belongs to a group of DH autoantibodies which targets a major epitope region of TG3 (epitope group 2; N-terminally oriented). DH63-B02 does not recognize a TG3/TG2 chimeric molecule with the N-terminal domain from TG3 suggests that the antibody binds to the catalytic core rather than the N-terminal domain. The antibody retained good reactivity to the inhibitor-bound enzyme without the C1C2 domains

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human esophagus
    Figure 1 IHC staining of human esophagus
    (Immunohistochemical staining of human esophagus shows strong cytoplasmic and nuclear positivity in squamous epithelial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4728/142446_B_5_1_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4728/142446_B_8_5.jpg
    Figure 3 Esophagus
    Figure 3 Esophagus
    (Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4728/142446_B_5_1.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4728/142446_A_7_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4728/142446_A_5_6.jpg
    RNA Expression
    Figure 6 RNA cell line category: Cell line enriched (EFO-21)
    Figure 6 RNA cell line category: Cell line enriched (EFO-21)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125780-TGM3

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG
    • Specificity
    • Human TGM3
    • Species Reactivity
    • Human
    • Clone
    • DH63-B02
    • Applications
    • ELISA

    Product Property

    • Purification
    • Protein A purified
    • Purity
    • >95% as determined by SDS-PAGE and SEC-HPLC analysis
    • Buffer
    • PBS, pH 7.4
    • Preservative
    • No preservatives
    • Storage
    • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • TGE; UHS2
    • Long Name
    • Transglutaminase 3
    • Sequence Similarities
    • Belongs to the transglutaminase superfamily. Transglutaminase family.
    • Cellular Localization
    • Cytoplasm
    • Post Translation Modifications
    • Activated by proteolytic processing.
      In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease.
      Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 or between Pro-465 and Phe-466.
      Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV.
    • Function
    • Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins.
      Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes.
      Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold.
      In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "TGM3"

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    IgG Antibody Products
    CAT Product Name Application Type
    MOB-2050z Mouse Anti-TGM3 Recombinant Antibody (clone 36C12) WB, ELISA, IHC Mouse IgG1
    MOB-2075CT Recombinant Mouse anti-Human TGM3 Monoclonal antibody (C6E) ICC/IF, WB

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