AbPlus™ Anti-TP53I3 Magnetic Beads (VS-0724-YC505) (CAT#: VS-0724-YC505)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-TP53I3 specific antibody

• Target
• TP53I3

• Immunogen
• Recombinant human PIG3/TP53I3, aa 1-332.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

• Alternative Names
• Tumor Protein P53 Inducible Protein 3; P53-Induced Gene 3 Protein; PIG3; Tumor Protein P53-Inducible Protein 3; Quinone Oxidoreductase Homolog; Quinone Oxidoreductase PIG3; EC 1.-.-.-;

• Gene ID
• 9540

• UniProt ID
• Q53FA7

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