Rabbit Anti-TRIM24 Recombinant Antibody (clone R09-3G6)
CAT#: VS3-FY1914
This anti-TRIM24 antibody detected positive in western blot analysis of TRIM24 in K562, Hela lysates. The recombinant monoclonal antibody demonstrates high specificity in binding to human TRIM24. This R09-3G6 antibody is validated for western blot analysis of TRIM24 in K562, Hela lysates.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43495/506_C10_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61717/1135_F6_2_selected.jpg
Normal Tissue
Figure 3 Thyroid gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43495/98179_B_2_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43495/98179_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Round or early spermatids Staining: Medium Intensity: Strong Quantity: <25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43495/98179_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43495/98179_A_8_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (AF22, HMC-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000122779-TRIM24
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WB
Figure 1 Anti-TRIM24 Antibody (VS3-FY1914) in WB.
The TRIM24 expression in K562, Hela lysates were detected using the anti-TRIM24 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human TRIM24
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TRIM24
- Species Reactivity
- Human
- Clone
- R09-3G6
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 117 kDa, while the observed molecular weight stands at 117 kDa.
- Related Disease
- Differentiated Thyroid Carcinoma and Aortic Malignant Tumor
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Tripartite Motif Containing 24; RING-Type E3 Ubiquitin Transferase TIF1-Alpha; Transcriptional Intermediary Factor 1; E3 Ubiquitin-Protein Ligase TRIM24; RING Finger Protein 82; TIF1-Alpha; RNF82; TIF1A; TIF1; Transcription Intermediary Factor 1-Alpha
- Gene ID
- 8805
- UniProt ID
- O15164
- Cellular Localization
- Cytoplasm, Mitochondrion, Nucleus
- Post Translation Modifications
- Phosphorylated at Ser-768 by ATM kinase induces ubiquitination and degradation during DNA damage. (O15164-TIF1A_HUMAN)
Sumoylated. (O15164-TIF1A_HUMAN)
Undergoes ubiquitination-mediated degradation in response to DNA damage. (O15164-TIF1A_HUMAN)
Ubiquitination at Lys325, Lys341, and Lys458 (NX_O15164 [NX_O15164-1])
Modification sites at PhosphoSitePlus (O15164)
Glycosylation from GlyGen (O15164) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_024302749.1; XP_054215260.1; NP_003843.3; NP_056989.2
- Function
- Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TRIM24"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2339MZ | Recombinant Mouse Anti-Human TRIM24 Antibody | IHC-P, WB | Mouse antibody |
| VS3-FY1487 | Recombinant Rabbit Anti-TRIM24 Antibody (clone R01-4B4) | WB | Rabbit IgG |
| VS-0625-FY1434 | Human Anti-TRIM24 Recombinant Antibody (clone 2506W1329) | ELISA, Spiked IP, IF, IP MS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3679 | Rabbit Anti-Trim24 Recombinant Antibody (clone DS3679AB) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2354 | Anti-TRIM24 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7520 | Anti-Mouse TRIM24 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7519 | Anti-Human TRIM24 Immunohistochemistry Kit | IHC |
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