FITC-DRB1*04:01/Human GAD65 (KGMAALPRLIAFTSEHSHFS) MHC Tetramer
CAT#: MHC-YF1314
This product is a MHC tetramer of biotinylated peptide/MHC complex composed GAD65-derived peptide of KGMAALPRLIAFTSEHSHFS sequence covering 265-284 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78177/163309_B_9_5.jpg
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Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- GAD65
- Antigen Species
- Human
- Peptide
- KGMAALPRLIAFTSEHSHFS
- Range
- 265-284
- Conjugate
- FITC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
- Alternative Names
- GAD65
- Gene ID
- 2572
- UniProt ID
- Q05329
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