Human Anti-IL33 (clone W25scFv88) scFv-Fc Chimera (CAT#: VS-0125-FY37)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• W25scFv88

• Applications
• Immunoassay

• Related Disease
• Autoimmune disease

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The correctly folded scFv-Fcs with strong binding affinity for human IL-33 stands out as a promising candidate for the development of a novel therapy targeting allergic and autoimmune conditions.

• Alternative Names
• Interleukin 33

• Gene ID
• 90865

• UniProt ID
• O95760

• Sequence Similarities
• Belongs to the IL-1 family. Highly divergent.

• Cellular Localization
• Chromosome, Cytoplasm, Cytoplasmic vesicle, Nucleus, Secreted

• Post Translation Modifications
• The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein.

• Protein Refseq
• NP_001186569.1

• Function
• Acts as an enhancer of polarization of alternatively activated macrophages.
  Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

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