Recombinant Human Anti-NY-ESO-1 Soluble TCR (C-Cys) (VS-0622-YF2761) (CAT#: VS-0622-YF2761)
Human TCR recognizes NY-ESO-1 peptide (AMPFATPM) in the context of HLA-B*3508. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in testis.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/ihc_selected.jpg
Figure 2 Low expression in endometrium 1.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/32112_B_4_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/32112_B_4_3_val_selected.jpg
Figure 3 Testis
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/32112_A_6_6.jpg
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/32112_A_6_6.jpg
Figure 4 RNA cell line category: Group enriched (U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000268651-CTAG1A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000268651-CTAG1A
Specifications
- Host Species
- Human
- Target
- NY-ESO-1
- Species Reactivity
- Human
- Epitope
- AMPFATPM
- MHC
- HLA-B*3508
- Type
- Soluble TCR (C-Cys)
- Related Disease
- Melanoma, breast cancer, lung cancer, prostate cancer, thyroid cancer, ovarian cancer, or synovial cell sarcoma.
- TCR Expression Strategy
- C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.
Target
- Alternative Names
- CTAG1A; CT6.1; CTAG; Cancer/Testis Antigen 6.1; Cancer/Testis Antigen 1; Autoimmunogenic Cancer/Testis Antigen NY-ESO-1; CTAG1; LAGE2A
- Gene ID
- 246100
- UniProt ID
- P78358
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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