Human Anti-RHOA/B (clone F7) scFv-Fc Chimera (CAT#: VS-0325-FY166)
This is a monoclonal antibody in scFv-Fc format that specifically recognizes the ADP-ribosylated forms of RhoA and RhoB, but not RhoC or unmodified RhoA.
Specific Inquiry
Specifications
- Immunogen
- GTP-locked mutant RhoAL63.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human RHOA/B
- Species Reactivity
- Human
- Clone
- F7
- Applications
- ELISA, Western Blot
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- RHOA, RHOB; Human RhoA and RhoB proteins
- Long Name
- Human RhoA and RhoB proteins
- Sequence Similarities
- Belongs to the small GTPase superfamily. Rho family.
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Membrane; Nucleus
- Post Translation Modifications
- (Microbial infection) Substrate for botulinum ADP-ribosyltransferase.
(Microbial infection) AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively.
AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells.
- Protein Refseq
- NP_001300870.1; NP_001300872.1; NP_001300873.1; NP_001300874.1; NP_001300875.1
- Function
- Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475, PubMed:31570889).
Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402).
Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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