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    Human Anti-TNRC6A scFv-Fc Chimera (VS-0325-FY51) (CAT#: VS-0325-FY51)

    This is an anti-TCR idiotype antibody, and its use in generating ADCs for the targeted therapy of T cell cancers. The aTCRA6 antibody specifically recognizes the unique TCR on the surface of malignant T cells.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, the Golgi apparatus & vesicles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/15305/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17869/40574_B_9_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17869/40574_A_7_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17869/40574_A_9_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17869/40574_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17869/40574_A_6_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/17869/40574_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000090905-TNRC6A

    Specifications

    • Immunogen
    • Soluble TCRA6 protein.
    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human TNRC6A
    • Species Reactivity
    • Human
    • Applications
    • Flow Cytometry

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Target

    • Alternative Names
    • Trinucleotide Repeat Containing 6A; Glycine-Tryptophan Protein Of 182 KDa; EMSY Interactor Protein; CAG Repeat Protein 26; GW182 Autoantigen; CAGH26; TNRC6; Trinucleotide Repeat-Containing Gene 6A Protein
    • Long Name
    • Trinucleotide Repeat Containing 6A
    • Sequence Similarities
    • Belongs to the GW182 family.
    • Cellular Localization
    • Cytoplasm
    • Post Translation Modifications
    • Modification sites at PhosphoSitePlus
      Modification sites at neXtProt
      Glycosylation from GlyGen 22 sites, 3 N-linked glycans (4 sites), 2 O-linked glycans (18 sites)
    • Function
    • TNRC6A (Trinucleotide repeat containing 6A) is a protein involved in microRNA-mediated gene silencing. It plays a crucial role in regulating gene expression at the post-transcriptional level.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    IgG Antibodies
    CAT Product Name Application Type
    MOB-1531z Mouse Anti-TNRC6A Recombinant Antibody (clone 30H2) WB, IF, IHC, IP Mouse IgG1, κ

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