Recombinant Mouse Anti-OMG Soluble TCR (ZIP-Fos/ZIP-Jun) (VS-0622-YF678) (CAT#: VS-0622-YF678)
Mouse TCR recognizes OMG peptide (TLDISNNRLESLPAH) in the context of HLA-DRB1*15:01. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Mouse soluble TCR. Please note that the activity is not guaranteed.
Specific Inquiry
Normal Tissue
Figure 1 High expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8206/120250_B_9_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8206/120250_B_9_5_val_selected.jpg
Figure 2 Low expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8206/120250_A_2_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8206/120250_A_2_3_val_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12693/120244_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12693/120244_B_8_5.jpg
Figure 4 Caudate
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12693/120244_B_7_7.jpg
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12693/120244_B_7_7.jpg
Specifications
- Host Species
- Mouse
- Target
- OMG
- Species Reactivity
- Human
- Epitope
- TLDISNNRLESLPAH
- MHC
- HLA-DRB1*15:01
- Type
- Soluble TCR (ZIP-Fos/ZIP-Jun)
- Related Disease
- Multiple Sclerosis (MS)
- TCR Expression Strategy
- ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.
Target
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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