Recombinant Anti-IL12RB1 Vesicular Antibody, EV Displayed (VS-0425-YC541)
CAT#: VS-0425-YC541
The Recombinant Anti-IL12RB1 Vesicular Antibody, EV Displayed (VS-0425-YC541) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL12RB1-expressed cells or tissues. IL12RB1 is a type I transmembrane protein part of the IL12 receptor complex, influencing IL12 signaling and T lymphocyte development. Mutations increase susceptibility to certain infections.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74414/1688_B12_33_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000096996-IL12RB1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL12RB1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 12 receptor subunit beta 1
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
- Alternative Names
- CD212, IL12RB
- Gene ID
- 3594
- UniProt ID
- P42701
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0084-FY | Human Anti-IL12RB1 Recombinant Antibody (clone mAb4) | ELISA | Human IgG1 |
| HPAB-0852-CN | Human Anti-IL12RB1 Recombinant Antibody (HPAB-0852-CN) | ELISA, FC | Human IgG4 |
| HPAB-0853-CN | Human Anti-IL12RB1 Recombinant Antibody (HPAB-0853-CN) | ELISA, FC | Human IgG4 |
| HPAB-0854-CN | Human Anti-IL12RB1 Recombinant Antibody (HPAB-0854-CN) | ELISA, FC | Human IgG4 |
| HPAB-674-FY | Mouse Anti-IL12RB1 Recombinant Antibody (clone mAb1) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0084-FY-S(P) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb4); scFv Fragment | ELISA | Human scFv |
| HPAB-674-FY-S(P) | Mouse Anti-IL12RB1 Recombinant Antibody (clone mAb1); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0845-FY-F(E) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb1); scFv Fragment | ELISA | Human scFv |
| HPAB-0847-FY-F(E) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb7); scFv Fragment | ELISA | Human scFv |
| HPAB-0848-FY-F(E) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb10); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0852-CN-F(E) | Human Anti-IL12RB1 Recombinant Antibody; Fab Fragment (HPAB-0852-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0853-CN-F(E) | Human Anti-IL12RB1 Recombinant Antibody; Fab Fragment (HPAB-0853-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0854-CN-F(E) | Human Anti-IL12RB1 Recombinant Antibody; Fab Fragment (HPAB-0854-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0845-FY-S(P) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb1); Fab Fragment | ELISA | Human Fab |
| HPAB-0847-FY-S(P) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb7); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1416 | AbPlus™ Anti-IL12RB1 Magnetic Beads (VS-0724-YC1416) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY127 | CytoStream™ Mouse Anti-IL12RB1 Recombinant Antibody (VS-0225-XY127) | FC | Mouse IgG2a, kappa |
| VS-0225-XY128 | CytoStream™ Mouse Anti-IL12RB1 Recombinant Antibody (VS-0225-XY128) | FC | Mouse IgG1, kappa |
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