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ABCC4
Loading...Anti-ABCC4 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Anti-ABCC4 Immunohistochemistry Kit (VS-0525-XY26)
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- Species Reactivity: Human
- Target: ABCC4
- Application: IHC
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- Anti-Mouse ABCC4 Immunohistochemistry Kit (VS-0525-XY27)
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- Species Reactivity: Human, Mouse
- Target: ABCC4
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants.
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Microglial cells, granulocytes, Erythroid cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Group enriched (HEL, HMC-1, RPTEC TERT1)
Interaction
Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); this interaction accelerates MRP4 internalization.
Molecular function
Translocase
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