ADRM1

Tetramer Products AbPlus Recombinant Antibody Products Formats

Anti-ADRM1 Recombinant Antibody Products

PE-B7/Human ADRM1 (SPTQPIQL) MHC Tetramer (MHC-LC1967)
- Class: Class I
- Antigen: ADRM1
- Antigen Species: Human
- Peptide: SPTQPIQL
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (CACO-2)

Interaction

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (PubMed:16990800). Interacts with the proteasomal scaffolding protein PSMD1 (PubMed:16990800,PubMed:16815440, PubMed:16906146, PubMed:20471946). Interacts with deubiquitinase UCHL5; this interaction activates the auto-inhibited UCHL5 by deoligomerizing it (PubMed:17139257, PubMed:24752541, PubMed:25702870, PubMed:25702872). Interacts with UBQLN2 and ubiquitin (PubMed:27396824).

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