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AFAP1

Anti-AFAP1 Products

Mouse Anti-AFAP1 Recombinant Antibody (clone 25A2) (MOB-3893z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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Anti-AFAP1 Immunohistochemistry Kit (VS-0525-XY201)
- Species Reactivity: Human
- Target: AFAP1
- Application: IHC
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Anti-Mouse AFAP1 Immunohistochemistry Kit (VS-0525-XY202)
- Species Reactivity: Human, Mouse, Rat
- Target: AFAP1
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene.

Predicted location

Intracellular

Single cell type specificity

Group enriched (Late spermatids, Early spermatids, Oligodendrocyte precursor cells, Inhibitory neurons, Extravillous trophoblasts)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Cell line enhanced (TIME)

Interaction

Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers (By similarity). Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB and PRKCI (By similarity).

Molecular function

Actin-binding

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