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AFDN
Loading...Anti-AFDN Products
- Anti-AFDN Immunohistochemistry Kit (VS-0525-XY203)
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- Species Reactivity: Human
- Target: AFDN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Adipocytes, Alveolar cells type 1, Breast glandular cells)
Immune cell specificity
Immune cell enhanced (memory B-cell)
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Interacts with F-actin, nectin and NECTIN3. Essential for the association of nectin and E-cadherin. Isoform 1/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1 and RIT2 (By similarity). Interacts with NRXN1 and BCR. Interacts with ADAM10; the interaction locks ADAM10 at adherens junctions following ADAM10 recruitment to adherens junctions by TSPAN33 (PubMed:30463011).
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