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AGRP
Anti-AGRP Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Hofbauer cells, Theca cells, Macrophages, Distal tubular cells, Leydig cells, Peritubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CACO-2)
Interaction
Interacts with melanocortin receptors MC3R, MC4R and MC5R.
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