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APCDD1

This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Endometrial stromal cells, Astrocytes, Oligodendrocyte precursor cells, Cholangiocytes, Melanocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, BJ hTERT+, HaCaT, HHSteC, HSkMC)

Interaction

Homodimer. Interacts with LRP5 and WNT3A.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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