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ATP12A

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene.
Protein class

Enzymes, Metabolic proteins, Plasma proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Basal respiratory cells, Club cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (SuSa)

Interaction

The ATPase pump is composed of a catalytic alpha subunit and an auxiliary non-catalytic beta subunit. The alpha subunit pairs with the beta subunit of gastric H(+)/K(+) ATPase ATP4B or the beta subunit of Na(+)/K(+) ATPases ATP1B1 and ATP1B3; this interaction is required for the formation of a functionally active pump and its targeting at the plasma membrane.

Molecular function

Translocase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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