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CABIN1
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For Research Use Only. Not For Clinical Use.
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of its target genes.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3. 3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.
Molecular function
Chromatin regulator
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