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CD244
Loading...Anti-CD244 ProductsBackground
Anti-CD244 Products
- Mouse Anti-CD244 Recombinant Antibody (clone OX122) (FAMAB-1575CQ)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: Block, WB, FC
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- Mouse Anti-CD244 Antibody (clone OX122), mRNA (FAMAB-1575CQ-mRNA)
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- Species Reactivity: Mouse
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- Rabbit Anti-CD244 Recombinant Antibody (VS-0723-WK284) (VS-0723-WK284)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- AbPlus™ Anti-CD244 Magnetic Beads (VS-0724-YC1302) (VS-0724-YC1302)
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- Target: CD244
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-CD244 Immunohistochemistry Kit (VS-0525-XY1147)
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- Species Reactivity: Human
- Target: CD244
- Application: IHC
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- Anti-Mouse CD244 Immunohistochemistry Kit (VS-0525-XY1148)
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- Species Reactivity: Mouse
- Target: CD244
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
CD244 (CD244 Molecule) is a Protein Coding gene. Diseases associated with CD244 include Rheumatoid Arthritis and Lymphoproliferative Syndrome, X-Linked, 1. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include receptor activity.
Protein class
CD markers, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (NK-cells, dendritic cells, T-cells, Kupffer cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (HEL, HMC-1, NB-4, U-937)
Interaction
Interacts with CD48 (PubMed:9841922,PubMed:27249817). Interacts (via phosphorylated ITSM 1-4) with SH2D1A (via SH2 domain); SH2D1A probably mediates association with FYN. Interacts (via phosphorylated ITSM 3) with PTPN11/SHP-2, INPP5D/SHIP1, PTPN6/SHP-1 and CSK; binding of SH2D1A/SAP prevents association with PTPN11, PTPN6 and CSK; conflictingly a similar association has been described for phosphorylated ITSM 1 also including GRB2 and PLCG1. Interacts weakly (via phosphorylated ITSM 2) with PTPN11/SHP-2 and CSK (PubMed:10358138, PubMed:10934222, PubMed:12458214, PubMed:24642916, PubMed:26221972, PubMed:15713798). Interacts with SH2D1B (PubMed:12458214, PubMed:24642916). Interacts with PIK3R1; PI3K recruits SH2D1A (PubMed:11815622). Interacts with MHC class I proteins; the interaction is proposed to prevent self-killing of NK cells.
Molecular function
Receptor
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