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CD37 & FcγRI

Engineered Antibody
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.
CD37 & FcγRI
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.
  • Anti-CD37 (K7153A)-SMCC-DM1 ADC (IMGN529) (ADC-L019)
    • Target: CD37
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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  • Anti-CD37-vc-MMAE ADC (ADC-037LZY)
    • Target: CD37
    • Linker: VC (Valine-citrulline)
    • Drug: MMAE (monomethyl auristatin E)
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  • Anti-CD37 (K7153A)-SMCC-DM1 ADC (ADC-064LCT)
    • Target: CD37
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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