CD74 & CD22

Anti-CD74 & CD22 Products

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Anti-Human CD22 Recombinant Antibody (TAB-176) (TAB-176)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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Anti-Human CD22 Recombinant Antibody (TAB-183-F(E)) (TAB-183-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fv - disulfide stabilized
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) (TAB-198)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG4, κ
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1716CL-S(P)) (TAB-1716CL-S(P))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1717CL-S(P)) (TAB-1717CL-S(P))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1718CL-S(P)) (TAB-1718CL-S(P))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1719CL-S(P)) (TAB-1719CL-S(P))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1720CL-S(P)) (TAB-1720CL-S(P))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1721CL-S(P)) (TAB-1721CL-S(P))
- Type: Human antibody
- Application: ELISA, FC, FuncS
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1722CL-S(P)) (TAB-1722CL-S(P))
- Type: Human antibody
- Application: ELISA, FC, FuncS
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Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1715CL-S(P)) (TAB-1715CL-S(P))
- Derivation: Human
- Type: Fully human antibody
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Humanized Anti-CD22 Recombinant Antibody (clone Pinatuzumab) (TAB-899)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1, κ
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) (TAB-1724CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib
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Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1725CL-S(P)) (TAB-1725CL-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Block, Cyt, ELISA, FuncS
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Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2) (TAB-0196CL-F(E))
- Application: ELISA, In vivo
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Afuco™ Anti-Human CD74 ADCC Recombinant Antibody (HuMax-CD74), ADCC Enhanced (AFC-131CL)
- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2-Cys) (TAB-0197CL-F(E))
- Application: ELISA, In vivo
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Mouse IgG1, kappa Anti-CD22 Recombinant Antibody (MOB-1248z) (MOB-1248z)
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IF, FC
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Mouse Anti-CD74 Recombinant Antibody (clone 24B6) (MOB-1542z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, IF, IHC, IP, FuncS
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Human Anti-CD74 Recombinant Antibody (TAB-139CL) (TAB-139CL)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1715CL-F(E)) (TAB-1715CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1716CL-F(E)) (TAB-1716CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1717CL-F(E)) (TAB-1717CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1718CL-F(E)) (TAB-1718CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1719CL-F(E)) (TAB-1719CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1729CL-S(P)) (TAB-1729CL-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: IF, FC
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Human Anti-CD74 Recombinant Antibody; scFv Fragment (TAB-0569CL-S(P)) (TAB-0569CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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Human Anti-CD74 Recombinant Antibody; scFv Fragment (TAB-0570CL-S(P)) (TAB-0570CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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Human Anti-CD74 Recombinant Antibody; scFv Fragment (TAB-0571CL-S(P)) (TAB-0571CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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Human Anti-CD74 Recombinant Antibody; scFv Fragment (TAB-0572CL-S(P)) (TAB-0572CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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Human Anti-CD74 Recombinant Antibody; scFv Fragment (TAB-0573CL-S(P)) (TAB-0573CL-S(P))
- Derivation: Phage display library
- Species Reactivity: Cynomolgus monkey
- Type: Human scFv
- Application: ELISA
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Human Anti-CD74 Recombinant Antibody; scFv Fragment (TAB-0574CL-S(P)) (TAB-0574CL-S(P))
- Derivation: Phage display library
- Species Reactivity: Cynomolgus monkey
- Type: Human scFv
- Application: ELISA
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Rat Anti-CD22 Recombinant Antibody (clone 2D6) (NEUT-315CQ)
- Species Reactivity: Mouse
- Type: Rat IgG1, κ
- Application: Block
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PE-H2-IAb/Human CD74 (KPVSKMRMATPLLMQAL) MHC Tetramer (MHC-LC2820)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: KPVSKMRMATPLLMQAL
- Conjugate: PE
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PE-H2-IAd/Human CD74 (KPVSKMRMATPLLMQAL) MHC Tetramer (MHC-LC2821)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: KPVSKMRMATPLLMQAL
- Conjugate: PE
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PE-H2-IAk/Human CD74 (KPVSKMRMATPLLMQAL) MHC Tetramer (MHC-LC2822)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: KPVSKMRMATPLLMQAL
- Conjugate: PE
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PE-DRB1*01:01/Human CD74 (LPKPPKPVSKMRMATPLLMQALPM) MHC Tetramer (MHC-LC2885)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: LPKPPKPVSKMRMATPLLMQALPM
- Conjugate: PE
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PE-DRB1*03:01/Human CD74 (LPKPPKPVSKMRMATPLLMQALPM) MHC Tetramer (MHC-LC2886)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: LPKPPKPVSKMRMATPLLMQALPM
- Conjugate: PE
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PE-DRB1*04:01/Human CD74 (LPKPPKPVSKMRMATPLLMQALPM) MHC Tetramer (MHC-LC2887)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: LPKPPKPVSKMRMATPLLMQALPM
- Conjugate: PE
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PE-DRB1*04:04/Human CD74 (LPKPPKPVSKMRMATPLLMQALPM) MHC Tetramer (MHC-LC2888)
- Class: Class II
- Antigen: CD74
- Antigen Species: Human
- Peptide: LPKPPKPVSKMRMATPLLMQALPM
- Conjugate: PE
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Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) (TAB-001LC-F(E))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) (TAB-002LC-F(E))
- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, SPR
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Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0569CL-F(E)) (TAB-0569CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0570CL-F(E)) (TAB-0570CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0571CL-F(E)) (TAB-0571CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2) (TAB-0196CL-S(P))
- Application: ELISA, In vivo
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Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) (MOB-0349MZ)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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Anti-Human CD22 Recombinant Antibody scFv Fragment (RFB4) (TAB-1728CL-S(P))
- Application: IF, FC
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Anti-Human CD22 Recombinant Antibody Fab Fragment(Bectumomab) (TAB-047-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab' - G2a - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, WB
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Recombinant Anti-Human CD22 Antibody Fab Fragment (MOB-1248z-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, RIA, FuncS
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Recombinant Anti-Human CD22 Antibody scFv Fragment (MOB-1248z-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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anti-CD22 immunotoxin RFB4 (scFv)-PE (AGTO-L048E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-DT (AGTO-L048D)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-Gel (AGTO-L048G)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Anti-Human CD74 VHH Single Domain Antibody (TAB-0011CL-VHH) (TAB-0011CL-VHH)
- Species Reactivity: Cross-react with mouse CD74
- Type: VHH
- Application: ELISA, FC, Internalization, Inhib, FuncS
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Anti-CD22 immunotoxin RFB4 (IgG)-RTA (AGTO-G077R)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD22 immunotoxin RFB4 (IgG)-Gel (AGTO-G077G)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD22 immunotoxin RFB4 (IgG)-PE (AGTO-G077E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD22 immunotoxin RFB4 (IgG)-DT (AGTO-G077D)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD22 immunotoxin RFB4 (IgG)-Sap (AGTO-G077S)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Recombinant Anti-Human CD74 VHH Single Domain Antibody (NAB-466-VHH)
- Species Reactivity: Human
- Type: Llama VHH
- Application: FUNC, FA, IP, ChiP
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) (TAB-1714CL-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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anti-CD22 immunotoxin RFB4 (scFv)-RTA (AGTO-L048R)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-Sap (AGTO-L048S)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1723CL-S(P)) (TAB-1723CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib
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Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1714CL-F(E)) (TAB-1714CL-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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Anti-CD74 (clone 006 (A))-vc-MMAE ADC (ADC-061CL)
- Target: CD74
- Linker: VC (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD74 (clone 005 (A))-vc-MMAE ADC (ADC-062CL)
- Target: CD74
- Linker: VC (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD22 (clone hu10F4)-MCC-DM1 ADC (ADC-027LZY)
- Target: CD22
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CD22-mc-vc-PABc-MMAE ADC (ADC-033LZY)
- Target: CD22
- Linker: mc-VC-PABc(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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Anti-CD22-mc-vc-PABc-NMS249 ADC (ADC-097LZY)
- Target: CD22
- Linker: mc-VC-PABc (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: NMS249
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Anti-CD22-AcBut-CalichDMH ADC (ADC-006LZY)
- Target: CD22
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: CalichDMH
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Anti-CD22 (clone HB22.7)-saporin ADC (ADC-154LZY)
- Target: CD22
- Drug: saporin
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Anti-CD22 (clone G5/44)-AcBut-CalichDMH ADC (ADC-003LZY)
- Target: CD22
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: CalichDMH
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Anti-CD22 (Inotuzumab)-calicheamicin ADC (CMC-544/inotuzumab ozogamicin) (ADC-L024)
- Target: CD22
- Linker: acetyl butyrate linker
- Drug: calicheamicin
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Anti-CD22 (CR011)-vc-MMAE ADC (RG7593) (ADC-L028)
- Target: CD22
- Linker: vc (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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Recombinant Anti-Human CD22 Antibody (Fab glycosylation) (Gly-001LC)
- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
- Classification: Fab glycosylation
- Glycosylation site: FR1 of VK
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Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC (ADC-211CL)
- Target: CD22
- Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v3)-MC-MMAF ADC (ADC-212CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC (ADC-213CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD22 (clone 5E8)-SMCC-DM1 ADC (ADC-214CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 7A2)-SMCC-DM1 ADC (ADC-215CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v1)-SMCC-DM1 ADC (ADC-216CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v2)-SMCC-DM1 ADC (ADC-217CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
- Target: CD22
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (10F4)-AcBut-Calicheamicin ADC (ADC-029LCT)
- Target: CD22
- Linker: AcBut
- Drug: Calicheamicin
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Anti-CD74 (clone 011 (B))-vc-MMAE ADC (ADC-060CL)
- Target: CD74
- Linker: VC (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD22-CL2A-SN-38 ADC (ADC-030LCT)
- Target: CD22
- Linker: CL2A
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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Anti-CD22-CL2E-SN-38 ADC (ADC-031LCT)
- Target: CD22
- Linker: CL2E
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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Anti-CD22-MC-MMAF ADC (ADC-032LCT)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22-MCC-DM1 ADC (ADC-033LCT)
- Target: CD22
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Compare

Anti-CD22 (clone 10F4v2)-MC-MMAF ADC (ADC-218CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
Compare

Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC (ADC-219CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Compare

Anti-CD22 (clone 10F4v3)-MC-MMAF ADC (ADC-220CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-221CL)
- Target: CD22
- Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC (ADC-222CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
Compare

Anti-CD22 (clone 10F4)-SMCC-DM1 ADC (ADC-223CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Compare

Anti-CD22 (clone RFB4)-SMCC-DM1 ADC (ADC-224CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Compare

Anti-CD22 (clone RFB4)-MC-vc-PAB-MMAF ADC (ADC-225CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAF (Monomethyl auristatin F)
Compare

Anti-CD74 (HuMax-CD74)-MC-vc-PAB-MMAF ADC (ADC-085LCT)
- Target: CD74
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAF (Monomethyl auristatin F)
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For Research Use Only. Not For Clinical Use.

Background

Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.

CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Undifferentiated Pleomorphic Sarcoma and Mantle Cell Lymphoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and amyloid-beta binding.