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CD74 & CD22

Engineered Antibody Glyco-Abs MHC
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
CD74 & CD22
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.
CD74 & CD22
  • Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
    • Target: CD22
    • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone RFB4)-SMCC-DM1 ADC (ADC-224CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4)-SMCC-DM1 ADC (ADC-223CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-221CL)
    • Target: CD22
    • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC (ADC-194LZY)
    • Target: CD22
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-193LZY)
    • Target: CD22
    • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC (ADC-219CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22-mc-vc-PABc-NMS249 ADC (ADC-097LZY)
    • Target: CD22
    • Linker: mc-VC-PABc (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
    • Drug: NMS249
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  • Anti-CD22-mc-vc-PABc-MMAE ADC (ADC-033LZY)
    • Target: CD22
    • Linker: mc-VC-PABc(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
    • Drug: MMAE (monomethyl auristatin E)
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  • Anti-CD22 (clone 10F4v2)-SMCC-DM1 ADC (ADC-217CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22-MCC-DM1 ADC (ADC-033LCT)
    • Target: CD22
    • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone hu10F4)-MCC-DM1 ADC (ADC-027LZY)
    • Target: CD22
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD22 (clone 10F4v1)-SMCC-DM1 ADC (ADC-216CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22-MC-MMAF ADC (ADC-032LCT)
    • Target: CD22
    • Linker: Mc (maleimidocaproyl)
    • Drug: MMAF (Monomethyl auristatin F)
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  • Anti-CD22 (clone 7A2)-SMCC-DM1 ADC (ADC-215CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 5E8)-SMCC-DM1 ADC (ADC-214CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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