Anti-CD22 (CR011)-vc-MMAE ADC (RG7593)
CAT#: ADC-L028
This ADC product is composed of an anti-CD22 antibody (clone CR011) conjuagated via a vc linker to MMAE (CR011-vc-MMAE). It has demonstrated a response in hematological malignancies, prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.



Specifications
- Antibody Overview
- Fully human IgG monoclonal antibody that binds to CD22
- Clone
- CR011
- Antibody Conjugation
- Human
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
- Alternative Names
- SIGLEC2; SIGLEC-2
- Gene ID
- 933
- UniProt ID
- P20273
Customer Review
There are currently no Customer reviews or questions for ADC-L028. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "CD22"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1248z | Mouse IgG1, kappa Anti-CD22 Recombinant Antibody (MOB-1248z) | IF, FC | Mouse IgG1, κ |
HPAB-0195-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0195-LSX) | Apop, Cyt, FC, WB, Inhib, FuncS, IF, ELISA | Human IgG |
HPAB-0196-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) | ELISA, FC, IP, RIA | Mouse IgG |
HPAB-0197-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) | ELISA, FC, FuncS | Human IgG |
HPAB-0198-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) | ELISA, WB, IF, FC, SPR | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1248z-F(E) | Recombinant Anti-Human CD22 Antibody Fab Fragment | IP, RIA, FuncS | Fab |
HPAB-N0324-YC-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-N0324-YC-F(E)) | FuncS | Mouse Fab |
HPAB-N0325-YC-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-N0325-YC-F(E)) | FuncS | Mouse Fab |
HPAB-0249-FY-F(E) | Recombinant Human Anti-CD22 Antibody Fab Fragment | F | Human Fab |
HPAB-1899LY-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-1899LY-F(E)) | ELISA, Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1248z-S(P) | Recombinant Anti-Human CD22 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
HPAB-1899LY-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1899LY-S(P)) | ELISA, Inhib | Mouse scFv |
HPAB-1900LY-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1900LY-S(P)) | ELISA, Inhib | Mouse scFv |
HPAB-0034-YJ-S(P) | Mouse Anti-CD22 Recombinant Antibody (clone HB22-23); scFv Fragment | Block | Mouse scFv |
HPAB-0709-FY-F(E) | Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-198 | Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized (from mouse) IgG4, κ |
TAB-1725CL-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1725CL-S(P)) | Block, Cyt, ELISA, FuncS | Humanized scFv |
TAB-1729CL-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1729CL-S(P)) | IF, FC | Humanized scFv |
TAB-1725CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) | Block, Cyt, ELISA, FuncS | Humanized Fab |
TAB-1729CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) | IF, FC | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L048E | anti-CD22 immunotoxin RFB4 (scFv)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L048D | anti-CD22 immunotoxin RFB4 (scFv)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L048G | anti-CD22 immunotoxin RFB4 (scFv)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L048R | anti-CD22 immunotoxin RFB4 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L048S | anti-CD22 immunotoxin RFB4 (scFv)-Sap | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1714CL | Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) | ELISA, WB | Mouse IgG |
TAB-1714CL-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) | ELISA, WB | Mouse scFv |
TAB-003LC | Mouse Anti-Human CD22 Recombinant Antibody | FC | |
TAB-004LC | Anti-Human CD22 Recombinant Antibody | FC | |
TAB-005LC | Mouse Anti-CD22 Recombinant Antibody (TAB-005LC) | FC, Cyt, Block, Apop, ROS assay, FuncS | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1715CL | Human Anti-CD22 Recombinant Antibody (TAB-1715CL) | Cyt, FuncS | Fully human antibody |
TAB-1716CL | Human Anti-CD22 Recombinant Antibody (TAB-1716CL) | Cyt, FuncS | Fully human antibody |
TAB-1717CL | Human Anti-CD22 Recombinant Antibody (TAB-1717CL) | Cyt, FuncS | Fully human antibody |
TAB-1718CL | Human Anti-CD22 Recombinant Antibody (TAB-1718CL) | Cyt, FuncS | Fully human antibody |
TAB-1719CL | Human Anti-CD22 Recombinant Antibody (TAB-1719CL) | ELISA | Fully human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1724CL | Human Anti-CD22 Recombinant Antibody (TAB-1724CL) | Inhib | Chimeric (mouse/human) IgG1, κ |
TAB-1724CL-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) | Inhib | Mouse scFv |
TAB-1724CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) | Inhib | Chimeric (mouse/human) Fab |
TAB-001LC | Human Anti-CD22 Recombinant Antibody (TAB-001LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-001LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-001LC | Recombinant Anti-Human CD22 Antibody (Fab glycosylation) | ELISA, FC | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-111LC | Recombinant Anti-Human CD22 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-315CQ | Rat Anti-CD22 Recombinant Antibody (clone 2D6) | Block | Rat IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0545 | Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) | IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-176 | Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-176) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-198 | Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-198) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0424-XY50 | AbPlus™ Anti-CD22 Magnetic Beads (DM13) | IP, Protein Purification | |
VS-0724-YC918 | AbPlus™ Anti-Cd22 Magnetic Beads (VS-0724-YC918) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY24 | CytoStream™ Mouse Anti-CD22 Recombinant Antibody (VS-0225-XY24) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-XY357 | Anti-CD22 Immunohistochemistry Kit | IHC | |
VS-0525-XY1143 | Anti-Human CD22 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-FY82 | Human Anti-CD22 (clone Inotuzumab) scFv-Fc Chimera | ELISA | Human IgG4, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC225 | Recombinant Anti-CD22 Vesicular Antibody, EV Displayed (VS-0425-YC225) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-YC201 | Recombinant Anti-CD22 (Epitope A x Epitope B) Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
Popular Products
Application: ELISA, Activ, Block
Application: FC, IHC-Fr, IP, ELISA, Block
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IB, ELISA, FC, FuncS
Application: IHC, ELISA, FC, WB, ADCC, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: FC, IHC-Fr, IP, ELISA, Block
Application: ELISA, Activ, Block
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.