Anti-CD22 (CR011)-vc-MMAE ADC (RG7593)

Name: Anti-CD22 (CR011)-vc-MMAE ADC (RG7593)
SKU: ADC-L028
Rating: 5 (1 reviews)

CAT#: ADC-L028

This ADC product is composed of an anti-CD22 antibody (clone CR011) conjuagated via a vc linker to MMAE (CR011-vc-MMAE). It has demonstrated a response in hematological malignancies, prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg

Normal Tissue Figure 2 Spleen

Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22

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Specifications

Antibody Overview
Fully human IgG monoclonal antibody that binds to CD22

Clone
CR011

Antibody Conjugation
Human

Linker
vc (valine-citrulline)

Linker Class/Description
Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Drug
MMAE (Monomethyl auristatin E)

Drug Class/Description
Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

Introduction
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.

Alternative Names
SIGLEC2; SIGLEC-2

Gene ID
933

UniProt ID
P20273

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Datasheet

Datasheet - ADC-L028.pdf

MSDS

MSDS - ADC-L028.pdf

COA

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