Anti-CD22 (CR011)-vc-MMAE ADC (RG7593)

CAT#: ADC-L028

This ADC product is composed of an anti-CD22 antibody (clone CR011) conjuagated via a vc linker to MMAE (CR011-vc-MMAE). It has demonstrated a response in hematological malignancies, prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.

Gene Expression
Figure 1 Lymph node Figure 2 Spleen Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)

Specifications

  • Antibody Overview
  • Fully human IgG monoclonal antibody that binds to CD22
  • Clone
  • CR011
  • Antibody Conjugation
  • Human
  • Linker
  • vc (valine-citrulline)
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  • Alternative Names
  • SIGLEC2; SIGLEC-2
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