Anti-CD22 immunotoxin RFB4 (IgG)-RTA (CAT#: AGTO-G077R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of B cell lymphoma.

Host: Mouse

Applications: This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.


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Normal Tissue

RNA Expression


Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • RFB4
  • Molecule Class
  • L kappa; IgG-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • B Cell Lymphoma

Target

  • Alternative Names
  • CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone RFB4"

See other products for "CD22"

Recombinant Antibody

CAT Product Name Application Type
MOB-1248z Recombinant Anti-Human CD22 Antibody WB, IHC, FuncS IgG
HPAB-N0324-YC Mouse Anti-CD22 Recombinant Antibody (HPAB-N0324-YC) FuncS Mouse IgG
HPAB-N0325-YC Mouse Anti-CD22 Recombinant Antibody (HPAB-N0325-YC) FuncS Mouse IgG
HPAB-0249-FY Recombinant Human Anti-CD22 Antibody F Human IgG1
HPAB-0370-FY Human Anti-CD22 Recombinant Antibody (HPAB-0370-FY) FC, FuncS, ELISA Humanized IgG

Immunotoxin

CAT Product Name Application Type
AGTO-G077E Anti-CD22 immunotoxin RFB4 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G077D Anti-CD22 immunotoxin RFB4 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G077G Anti-CD22 immunotoxin RFB4 (IgG)-Gel Cytotoxicity assay, Function study
AGTO-G077S Anti-CD22 immunotoxin RFB4 (IgG)-Sap Cytotoxicity assay, Function study
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-0196CL Anti-Human CD22 Recombinant Antibody (hLL2) Inhib, Cyt, FC, WB
TAB-0197CL Anti-Human CD22 Recombinant Antibody (hLL2-Cys) ELISA, In vivo
TAB-0196CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2) ELISA, In vivo
TAB-1721CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.1) ELISA, FC, FuncS Human antibody
TAB-1722CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.2) ELISA, FC, FuncS Human antibody

Mouse Antibody

CAT Product Name Application Type
TAB-1714CL Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) ELISA, WB Mouse IgG
TAB-1728CL Anti-Human CD22 Recombinant Antibody (RFB4) IF, FC
TAB-003LC Mouse Anti-Human CD22 Recombinant Antibody FC
TAB-004LC Anti-Human CD22 Recombinant Antibody FC
TAB-005LC Mouse Anti-CD22 Recombinant Antibody (TAB-005LC) FC, Cyt, Block, Apop, ROS assay, FuncS Mouse IgG2b

Humanized Antibody

CAT Product Name Application Type
TAB-1725CL Human Anti-CD22 Recombinant Antibody (TAB-1725CL) Block, Cyt, ELISA, FuncS Humanized IgG
TAB-1729CL Human Anti-CD22 Recombinant Antibody (TAB-1729CL) IF, FC Humanized IgG
TAB-1725CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) Block, Cyt, ELISA, FuncS Humanized Fab
TAB-1729CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) IF, FC Humanized Fab
TAB-002LC-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) ELISA, SPR Humanized antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) Inhib Mouse scFv
TAB-1724CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) Inhib Chimeric (mouse/human) Fab
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) ELISA Mouse scFv
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab
HPAB-0198-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-N0324-YC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0324-YC-S(P)) FuncS Mouse scFv
HPAB-N0325-YC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0325-YC-S(P)) FuncS Mouse scFv
HPAB-0370-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) ELISA Humanized scFv
HPAB-0371-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0371-FY-S(P)) Inhib Humanized scFv
HPAB-2052-FY-S(P) Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment FC Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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