Anti-CD22 immunotoxin RFB4 (IgG)-RTA (CAT#: AGTO-G077R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of B cell lymphoma.

Host: Mouse

Applications: This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.


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Normal Tissue

RNA Expression


Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • RFB4
  • Molecule Class
  • L kappa; IgG-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • B Cell Lymphoma

Target

  • Alternative Names
  • CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone RFB4"

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Humanized Antibody

CAT Product Name Application Type
TAB-176 Anti-Human CD22 Recombinant Antibody (Epratuzumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1
TAB-1725CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) Block, Cyt, ELISA, FuncS Humanized Fab
TAB-1729CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) IF, FC Humanized Fab
TAB-002LC Anti-Human CD22 Recombinant Antibody (VM1000) FC, ELISA, SPR, FuncS Humanized antibody
TAB-002LC-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) ELISA, SPR Humanized antibody

Mouse Antibody

CAT Product Name Application Type
TAB-183-F(E) Anti-Human CD22 Recombinant Antibody (Moxetumomab Pasudotox) FuncS, IF, Neut, ELISA, FC, IP, ICC Fv - disulfide stabilized
TAB-047-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment(Bectumomab) ELISA, FC, IP, FuncS, IF, Neut, WB Fab' - G2a - kappa
TAB-003LC-S(P) Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-004LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-005LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-005LC-S(P)) FC Mouse scFv

Immunotoxin

CAT Product Name Application Type
AGTO-G077S Anti-CD22 immunotoxin RFB4 (IgG)-Sap Cytotoxicity assay, Function study
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L048D anti-CD22 immunotoxin RFB4 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L048G anti-CD22 immunotoxin RFB4 (scFv)-Gel Cytotoxicity assay, Functional assay
AGTO-L048R anti-CD22 immunotoxin RFB4 (scFv)-RTA Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-1715CL Anti-Human CD22 Recombinant Antibody (12C5) Cyt, FuncS Fully human antibody
TAB-1716CL Anti-Human CD22 Recombinant Antibody (19A3) Cyt, FuncS Fully human antibody
TAB-1717CL Anti-Human CD22 Recombinant Antibody (16F7) Cyt, FuncS Fully human antibody
TAB-1721CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.1) ELISA, FC, FuncS Human antibody
TAB-1722CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.2) ELISA, FC, FuncS Human antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL Human Anti-CD22 Recombinant Antibody (TAB-1724CL) Inhib Chimeric (mouse/human) IgG1, κ
TAB-1724CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) Inhib Mouse scFv
TAB-1724CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) Inhib Chimeric (mouse/human) Fab
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Recombinant Antibody

CAT Product Name Application Type
MOB-0349MZ Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) ELISA Mouse IgG1
FAMAB-0046YC Mouse Anti-CD22 Recombinant Antibody (clone m5/44) ELISA, Cyt Mouse IgG1
FAMAB-0047YC Human Anti-CD22 Recombinant Antibody (clone g5/44) ELISA, Cyt Humanized IgG4
FAMAB-0048YC Human Anti-CD22 Recombinant Antibody (clone ch5/44) ELISA Chimeric (mouse/human) IgG
HPAB-N0324-YC Mouse Anti-CD22 Recombinant Antibody (HPAB-N0324-YC) FuncS Mouse IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab
HPAB-0198-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-N0324-YC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0324-YC-S(P)) FuncS Mouse scFv
HPAB-N0325-YC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0325-YC-S(P)) FuncS Mouse scFv
HPAB-0709-FY-F(E) Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment ELISA Mouse scFv
HPAB-0370-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) ELISA Humanized scFv
HPAB-2052-FY-S(P) Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment FC Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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