Anti-CD22 (Inotuzumab)-calicheamicin ADC (CMC-544/inotuzumab ozogamicin) (CAT#: ADC-L024)

This ADC product is composed of an anti-CD22 antibody (Inotuzumab) conjuagated to calicheamicin (inotuzumab-calicheamicin). It has demonstrated a response in NHL treatment by a MOA (Mechanism of Action) of Calicheamicins target DNA and cause strand scission. Calicheamicins bind with DNA in the minor groove.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized IgG4k antibody inotuzumab (Anti-CD22)
  • Clone
  • Inotuzumab
  • Antibody Conjugation
  • Humanized
  • Linker
  • acetyl butyrate linker
  • Drug
  • calicheamicin
  • Drug Class/Description
  • Class: Calicheamicin
    Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

Target

  • Introduction
  • CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  • Alternative Names
  • SIGLEC2; SIGLEC-2

Downloads

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Humanized Antibody

CAT Product Name Application Type
TAB-176 Anti-Human CD22 Recombinant Antibody (Epratuzumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1
TAB-899 Humanized Anti-CD22 Recombinant Antibody (clone Pinatuzumab) FC, IP, ELISA, Neut, FuncS, IF, ICC Humanized (from mouse) IgG1, κ
TAB-1725CL Human Anti-CD22 Recombinant Antibody (TAB-1725CL) Block, Cyt, ELISA, FuncS Humanized IgG
TAB-1729CL Human Anti-CD22 Recombinant Antibody (TAB-1729CL) IF, FC Humanized IgG
TAB-002LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (VM1000) ELISA, SPR Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G077E Anti-CD22 immunotoxin RFB4 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G077D Anti-CD22 immunotoxin RFB4 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G077G Anti-CD22 immunotoxin RFB4 (IgG)-Gel Cytotoxicity assay, Function study
AGTO-G077R Anti-CD22 immunotoxin RFB4 (IgG)-RTA Cytotoxicity assay, Function study
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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