Anti-CD22 immunotoxin RFB4 (IgG)-Sap (CAT#: AGTO-G077S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of B cell lymphoma.

Host: Mouse

Applications: This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.


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Normal Tissue

RNA Expression


Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • RFB4
  • Molecule Class
  • L kappa; IgG-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • B Cell Lymphoma

Target

  • Alternative Names
  • CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; saporin; saporin-6; saporin-S72; SAP

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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scFv Fragment Antibody

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HPAB-0709-FY-F(E) Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment ELISA Mouse scFv
HPAB-0370-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) ELISA Humanized scFv
HPAB-0371-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0371-FY-S(P)) Inhib Humanized scFv

Mouse Antibody

CAT Product Name Application Type
TAB-047-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment(Bectumomab) ELISA, FC, IP, FuncS, IF, Neut, WB Fab' - G2a - kappa
TAB-1714CL Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) ELISA, WB Mouse IgG
TAB-1728CL Anti-Human CD22 Recombinant Antibody (RFB4) IF, FC
TAB-003LC-S(P) Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-004LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment FC

Humanized Antibody

CAT Product Name Application Type
TAB-899 Humanized Anti-CD22 Recombinant Antibody (clone Pinatuzumab) FC, IP, ELISA, Neut, FuncS, IF, ICC Humanized (from mouse) IgG1, κ
TAB-1725CL-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1725CL-S(P)) Block, Cyt, ELISA, FuncS Humanized scFv
TAB-1729CL-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1729CL-S(P)) IF, FC Humanized scFv
TAB-002LC Anti-Human CD22 Recombinant Antibody (VM1000) FC, ELISA, SPR, FuncS Humanized antibody
TAB-002LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (VM1000) ELISA, SPR Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G077E Anti-CD22 immunotoxin RFB4 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G077D Anti-CD22 immunotoxin RFB4 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G077G Anti-CD22 immunotoxin RFB4 (IgG)-Gel Cytotoxicity assay, Function study
AGTO-G077R Anti-CD22 immunotoxin RFB4 (IgG)-RTA Cytotoxicity assay, Function study
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-0196CL Anti-Human CD22 Recombinant Antibody (hLL2) Inhib, Cyt, FC, WB
TAB-0197CL Anti-Human CD22 Recombinant Antibody (hLL2-Cys) ELISA, In vivo
TAB-1715CL Anti-Human CD22 Recombinant Antibody (12C5) Cyt, FuncS Fully human antibody
TAB-0196CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2) ELISA, In vivo
TAB-0197CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2-Cys) ELISA, In vivo

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) Inhib Mouse scFv
TAB-1724CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) Inhib Chimeric (mouse/human) Fab
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) ELISA Mouse scFv
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab
HPAB-0198-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) ELISA, FC Mouse Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-0249-FY Recombinant Human Anti-CD22 Antibody F Human IgG1
HPAB-1899LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1899LY) ELISA, Inhib Mouse IgG
HPAB-1900LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1900LY) ELISA, Inhib Mouse IgG
HPAB-1901LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1901LY) ELISA, Inhib Mouse IgG
HPAB-1902LY Mouse Anti-CD22 Recombinant Antibody (HPAB-1902LY) ELISA, Inhib Mouse IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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