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Anti-CD22 immunotoxin RFB4 (IgG)-DT (AGTO-G077D)

This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of B cell lymphoma.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
RFB4
Molecule Class
L kappa; IgG-DT
Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
B Cell Lymphoma
Target
Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14
Entrez Gene ID
933
UniProt ID
P20273

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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anti-CD22 immunotoxin RFB4 (scFv)-Sap    ( AGTO-L048S )
Recombinant Humanized Anti-CD22 Antibody Fab Fragment (g5/44)    ( FAMAB-0047-YC-F(E) )
Anti-Human CD22 Therapeutic Antibody (RHOv2ACD/RKA)    ( TAB-1725CL )
Anti-Human CD22 Therapeutic Antibody (21F6)    ( TAB-1720CL )
Anti-Human CD22 Therapeutic Antibody scFv Fragment (hLL2-Cys)    ( TAB-0197CL-S(P) )
Anti-Human CD22 Therapeutic Antibody (RFB4)    ( TAB-1728CL )
>> MORE
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