Anti-Human CD22 Recombinant Antibody (hLL2-Cys) (CAT#: TAB-0197CL)
The anti-CD22 Antibody-Drug Conjugates comprise a drug moiety, an anti-CD22 antibody and a hydrophilic self-immolative linker. The antibody in this ADC compound specifically target human cluster of differentiation-22, which belongs to the SIGLEC family of lections. Therefore the anti-CD22 ADC compound can be used in the treatment or diagnosis of hematological malignancy.
Host: Human
Specific Inquiry
Normal Tissue
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
Figure 2 Spleen
(Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
(Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
Specifications
- Host Species
- Human
- Specificity
- Human
- Clone
- hLL2-Cys
- Related Disease
- Hematological malignancy
Target
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;
- Gene ID
- 933
- UniProt ID
- P20273
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-176 | Anti-Human CD22 Recombinant Antibody (Epratuzumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-1725CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) | Block, Cyt, ELISA, FuncS | Humanized Fab |
| TAB-1729CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) | IF, FC | Humanized Fab |
| TAB-002LC | Anti-Human CD22 Recombinant Antibody (VM1000) | FC, ELISA, SPR, FuncS | Humanized antibody |
| TAB-002LC-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (VM1000) | ELISA, SPR | Humanized antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
| TAB-183-F(E) | Anti-Human CD22 Recombinant Antibody (Moxetumomab Pasudotox) | FuncS, IF, Neut, ELISA, FC, IP, ICC | Fv - disulfide stabilized |
| TAB-1714CL | Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) | ELISA, WB | Mouse IgG |
| TAB-1728CL | Anti-Human CD22 Recombinant Antibody (RFB4) | IF, FC | |
| TAB-003LC-F(E) | Mouse Anti-Human CD22 Recombinant Antibody Fab Fragment | FC | |
| TAB-004LC-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment | FC |
Immunotoxin
| CAT | Product Name | Application | Type |
| AGTO-G077E | Anti-CD22 immunotoxin RFB4 (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G077D | Anti-CD22 immunotoxin RFB4 (IgG)-DT | Cytotoxicity assay, Function study | |
| AGTO-G077G | Anti-CD22 immunotoxin RFB4 (IgG)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G077R | Anti-CD22 immunotoxin RFB4 (IgG)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G077S | Anti-CD22 immunotoxin RFB4 (IgG)-Sap | Cytotoxicity assay, Function study |
Human Antibody
| CAT | Product Name | Application | Type |
| TAB-0196CL | Anti-Human CD22 Recombinant Antibody (hLL2) | Inhib, Cyt, FC, WB | |
| TAB-1721CL-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.1) | ELISA, FC, FuncS | Human antibody |
| TAB-1722CL-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.2) | ELISA, FC, FuncS | Human antibody |
| TAB-1721CL-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.1) | ELISA, FC, FuncS | Human antibody |
| TAB-1722CL-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.2) | ELISA, FC, FuncS | Human antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
| TAB-1724CL-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) | Inhib | Mouse scFv |
| TAB-1724CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) | Inhib | Chimeric (mouse/human) Fab |
| TAB-001LC | Human Anti-CD22 Recombinant Antibody (TAB-001LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-001LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) | ELISA | Mouse scFv |
| TAB-001LC-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) | ELISA | Chimeric antibody (mouse/human) |
Fab Glycosylation
| CAT | Product Name | Application | Type |
| Gly-001LC | Recombinant Anti-Human CD22 Antibody (Fab glycosylation) | ELISA, FC | Mouse antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
| Gly-111LC | Recombinant Anti-Human CD22 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
Blocking Antibody
| CAT | Product Name | Application | Type |
| NEUT-315CQ | Rat Anti-CD22 Recombinant Antibody (clone 2D6) | Block | Rat IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
| MOR-0545 | Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) | IP, WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
| HPAB-0195-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0195-LSX) | Apop, Cyt, FC, WB, Inhib, FuncS, IF, ELISA | Human IgG |
| HPAB-0196-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) | ELISA, FC, IP, RIA | Mouse IgG |
| HPAB-0197-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) | ELISA, FC, FuncS | Human IgG |
| HPAB-0198-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) | ELISA, WB, IF, FC, SPR | Mouse IgG |
| HPAB-0199-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) | ELISA, FC | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0194-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) | ELISA | Mouse Fab |
| HPAB-0195-LSX-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0196-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) | ELISA | Mouse Fab |
| HPAB-0197-LSX-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0198-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) | ELISA, FC | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| FAMAB-0046-YC-S(P) | Mouse Anti-CD22 Recombinant Antibody (clone m5/44); scFv Fragment | ELISA, Cyt | Mouse scFv |
| FAMAB-0047-YC-S(P) | Human Anti-CD22 Recombinant Antibody (clone g5/44); scFv Fragment | ELISA, Cyt | Humanized scFv |
| HPAB-N0324-YC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0324-YC-S(P)) | FuncS | Mouse scFv |
| HPAB-N0325-YC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0325-YC-S(P)) | FuncS | Mouse scFv |
| HPAB-2052-FY-S(P) | Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment | FC | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-176 | Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-198 | Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot
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