Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC (CAT#: ADC-211CL)

• Antibody Overview
• A118C Thio hu 10F4v3

• Clone
• 10F4v3

• Antibody Conjugation
• Thio

• Linker
• BMPEO (bis-maleimido-trioxyethylene glycol)

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

• Alternative Names
• CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

• Gene ID
• 933

• UniProt ID
• P20273

• ADC-212CL
• Anti-CD22 (clone 10F4v3)-MC-MMAF ADC

• ADC-213CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-194LZY
• Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC

• ADC-219CL
• Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC

• ADC-195LZY
• Anti-CD22 (clone 10F4v3)-mc-vc-PABC-MMAE ADC

• ADC-220CL
• Anti-CD22 (clone 10F4v3)-MC-MMAF ADC

• ADC-221CL
• Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC

• ADC-222CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-228CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-230CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

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