Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC (CAT#: ADC-211CL)

This ADC product is composed of an anti-CD22 antibody (clone 10F4v3) conjugated via BMPEO linker to DM1(hu 10F4v3 HC(A118C) Thio-engineered Antibody-BMPEO-DM1). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Normal Tissue

RNA Expression


Specifications

  • Antibody Overview
  • A118C Thio hu 10F4v3
  • Clone
  • 10F4v3
  • Antibody Conjugation
  • Thio
  • Linker
  • BMPEO (bis-maleimido-trioxyethylene glycol)
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
    CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
  • Alternative Names
  • CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 10F4v3"

See other products for "CD22"

Fab Fragment Antibody

CAT Product Name Application Type
MOB-1248z-F(E) Recombinant Anti-Human CD22 Antibody Fab Fragment IP, RIA, FuncS Fab
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab

Immunotoxin

CAT Product Name Application Type
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L048D anti-CD22 immunotoxin RFB4 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L048G anti-CD22 immunotoxin RFB4 (scFv)-Gel Cytotoxicity assay, Functional assay
AGTO-L048R anti-CD22 immunotoxin RFB4 (scFv)-RTA Cytotoxicity assay, Functional assay
AGTO-L048S anti-CD22 immunotoxin RFB4 (scFv)-Sap Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-1715CL Anti-Human CD22 Recombinant Antibody (12C5) Cyt, FuncS Fully human antibody
TAB-0196CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2) ELISA, In vivo
TAB-0197CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2-Cys) ELISA, In vivo
TAB-0196CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2) ELISA, In vivo
TAB-0197CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2-Cys) ELISA, In vivo

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL Human Anti-CD22 Recombinant Antibody (TAB-1724CL) Inhib Chimeric (mouse/human) IgG1, κ
TAB-1724CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) Inhib Mouse scFv
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) ELISA Mouse scFv
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-1714CL-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1714CL-F(E)) ELISA, WB Mouse Fab
TAB-1723CL-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1723CL-F(E)) Inhib Mouse Fab
TAB-1728CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (RFB4) IF, FC
TAB-003LC-S(P) Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-004LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment FC

Humanized Antibody

CAT Product Name Application Type
TAB-1725CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) Block, Cyt, ELISA, FuncS Humanized Fab
TAB-1729CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) IF, FC Humanized Fab
TAB-002LC Anti-Human CD22 Recombinant Antibody (VM1000) FC, ELISA, SPR, FuncS Humanized antibody
TAB-002LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (VM1000) ELISA, SPR Humanized antibody
TAB-002LC-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) ELISA, SPR Humanized antibody

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Recombinant Antibody

CAT Product Name Application Type
MOB-0349MZ Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) ELISA Mouse IgG1
FAMAB-0046YC Mouse Anti-CD22 Recombinant Antibody (clone m5/44) ELISA, Cyt Mouse IgG1
FAMAB-0047YC Human Anti-CD22 Recombinant Antibody (clone g5/44) ELISA, Cyt Humanized IgG4
FAMAB-0048YC Human Anti-CD22 Recombinant Antibody (clone ch5/44) ELISA Chimeric (mouse/human) IgG
HPAB-N0324-YC Mouse Anti-CD22 Recombinant Antibody (HPAB-N0324-YC) FuncS Mouse IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1899LY-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1899LY-S(P)) ELISA, Inhib Mouse scFv
HPAB-1900LY-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1900LY-S(P)) ELISA, Inhib Mouse scFv
HPAB-1901LY-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1901LY-S(P)) ELISA, Inhib Mouse scFv
HPAB-1902LY-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1902LY-S(P)) ELISA, Inhib Mouse scFv
HPAB-2052-FY-S(P) Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment FC Human scFv

Customer Reviews and Q&As

Submit a review or a question
Thare are currently no Customer reviews or questions for ADC-211CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

Send Inquiry

© 2022 Creative BioLabs. All Rights Reserved
  • 0
  • 0

Cart