anti-CD22 immunotoxin RFB4 (scFv)-Gel (CAT#: AGTO-L048G)

This immunotoxin was achieved by conjugating/fusing the Anti-CD22 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of leukemia.

Host: Mouse

Applications: This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.


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Normal Tissue

RNA Expression


Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • RFB4
  • Molecule Class
  • scFv-Gel
  • Toxin Description
  • Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Leukemia

Target

  • Alternative Names
  • CD22; CD22 antigen; Lyb8; Lyb-8; A530093D23; B-cell receptor CD22; BL-CAM; siglec-2; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid-binding Ig-like lectin 2; Leukemia; Gelonin; Gel

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone RFB4"

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Humanized Antibody

CAT Product Name Application Type
TAB-176 Anti-Human CD22 Recombinant Antibody (Epratuzumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1
TAB-198 Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized (from mouse) IgG4, κ
TAB-1725CL Human Anti-CD22 Recombinant Antibody (TAB-1725CL) Block, Cyt, ELISA, FuncS Humanized IgG
TAB-1725CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) Block, Cyt, ELISA, FuncS Humanized Fab
TAB-1729CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) IF, FC Humanized Fab

Immunotoxin

CAT Product Name Application Type
AGTO-G077E Anti-CD22 immunotoxin RFB4 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G077D Anti-CD22 immunotoxin RFB4 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G077G Anti-CD22 immunotoxin RFB4 (IgG)-Gel Cytotoxicity assay, Function study
AGTO-G077R Anti-CD22 immunotoxin RFB4 (IgG)-RTA Cytotoxicity assay, Function study
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-0196CL Anti-Human CD22 Recombinant Antibody (hLL2) Inhib, Cyt, FC, WB
TAB-0196CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2) ELISA, In vivo
TAB-0197CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2-Cys) ELISA, In vivo
TAB-1721CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.1) ELISA, FC, FuncS Human antibody
TAB-1722CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.2) ELISA, FC, FuncS Human antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL Human Anti-CD22 Recombinant Antibody (TAB-1724CL) Inhib Chimeric (mouse/human) IgG1, κ
TAB-1724CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) Inhib Mouse scFv
TAB-1724CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) Inhib Chimeric (mouse/human) Fab
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-003LC Mouse Anti-Human CD22 Recombinant Antibody FC
TAB-004LC Anti-Human CD22 Recombinant Antibody FC
TAB-005LC Mouse Anti-CD22 Recombinant Antibody (TAB-005LC) FC, Cyt, Block, Apop, ROS assay, FuncS Mouse IgG2b
TAB-003LC-S(P) Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-004LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment FC

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0195-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0195-LSX) Apop, Cyt, FC, WB, Inhib, FuncS, IF, ELISA Human IgG
HPAB-0196-LSX Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) ELISA, FC, IP, RIA Mouse IgG
HPAB-0197-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) ELISA, FC, FuncS Human IgG
HPAB-0198-LSX Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) ELISA, WB, IF, FC, SPR Mouse IgG
HPAB-0199-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) ELISA, FC Human IgG1

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab
HPAB-0198-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-N0324-YC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0324-YC-S(P)) FuncS Mouse scFv
HPAB-N0325-YC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0325-YC-S(P)) FuncS Mouse scFv
HPAB-1899LY-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1899LY-S(P)) ELISA, Inhib Mouse scFv
HPAB-0709-FY-F(E) Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment ELISA Mouse scFv
HPAB-2052-FY-S(P) Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment FC Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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