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CDKN3
Loading...Anti-CDKN3 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, IHC
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- Anti-CDKN3 Immunohistochemistry Kit (VS-0525-XY1347)
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- Species Reactivity: Human
- Target: CDKN3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids, Spermatocytes)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.
Molecular function
Hydrolase, Protein phosphatase
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