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CLCNKA
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For Research Use Only. Not For Clinical Use.
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (U-266/70)
Interaction
Homodimer (PubMed:17562318). Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle (By similarity).
Molecular function
Chloride channel, Ion channel, Voltage-gated channel
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