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CNTFR
Anti-CNTFR Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Muller glia cells, Astrocytes, Paneth cells, Fibroblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AF22, SH-SY5Y)
Interaction
Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation (PubMed:26858303). Component of a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR which interacts with the neuroprotective peptide humanin (PubMed:19386761).
Molecular function
Receptor
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