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CPLX2
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For Research Use Only. Not For Clinical Use.
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.
Predicted location
Intracellular
Single cell type specificity
Group enriched (Horizontal cells, Excitatory neurons, Enteroendocrine cells, Inhibitory neurons, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (A549, Hep G2, SCLC-21H)
Interaction
Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
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