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DLG1
Anti-DLG1 Recombinant Antibody Products
- Rabbit Anti-Dlg1 Recombinant Antibody (VS-0522-LC32) (VS-0522-LC32)
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- Species Reactivity: Rat, Mouse
- Type: Rabbit IgG
- Application: IB, IHC, IP
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- Rat Anti-Dlg1 Recombinant Antibody (VS-0522-LC31) (VS-0522-LC31)
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- Species Reactivity: Rat, Mouse
- Type: Rat IgG2b
- Application: IB, IHC, IP
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- Mouse Anti-Dlg1 Recombinant Antibody (VS-0522-LC30) (VS-0522-LC30)
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- Species Reactivity: Rat, Mouse
- Type: Mouse IgG1
- Application: IB, IHC, IP
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- Anti-DLG1 Immunohistochemistry Kit (VS-0325-XY672)
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- Species Reactivity: Human, Mouse, Rat
- Target: DLG1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Excitatory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homotetramer (Probable). Interacts (via guanylate kinase-like domain) with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A (By similarity). Interacts (via guanylate kinase-like domain) with KIF13B (PubMed:10859302). May interact with HTR2A (By similarity). Interacts (via PDZ domains) with GRIA1 (By similarity). Interacts (via PDZ domains) with GRIN2A (By similarity). Interacts (via PDZ domains) with KCND2 and KCND3 (PubMed:19213956). Interacts (via PDZ domains) with KCNA1, KCNA2, KCNA3 and KCNA4 (PubMed:7477295). Interacts (via PDZ domains) with ADGRA3 (PubMed:15021905). Interacts with KCNF1 (PubMed:12445884). Interacts with CAMK2 (By similarity). Interacts with cytoskeleton-associated protein EPB41 (PubMed:7937897, PubMed:8922391). Interacts with cytoskeleton-associated protein EZR (By similarity). Found in a complex with KCNA5 and CAV3 (By similarity). Found in a complex with APC and CTNNB1 (PubMed:8638125, PubMed:10656683). Interacts with CDH1 through binding to PIK3R1 (PubMed:14699157). Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12 (By similarity). Interacts with TOPK (PubMed:10779557). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (PubMed:17237226, PubMed:17332497, PubMed:20702775). May interact with TJAP1 (PubMed:11602598). Interacts with PTEN (By similarity). Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts with SFPQ (PubMed:20605917). Interacts (via PDZ domains) with ADGRA2 (via PDZ-binding motif) (PubMed:15021905, PubMed:25558062). Interacts with ADAM10; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (PubMed:23676497). Interacts with DGKI (via PDZ-binding motif) (By similarity). Interacts (via PDZ domains) with MARCHF2 (via PDZ domain); the interaction leads to DLG1 ubiqtuitination and degradation (PubMed:17980554). (Microbial infection) Interacts with HTLV-1 protein Tax. (Microbial infection) Interacts with human papillomavirus 18/HPV-18 protein E6.
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